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Optics Express

Optics Express

  • Editor: Michael Duncan
  • Vol. 11, Iss. 4 — Feb. 24, 2003
  • pp: 291–298

Preliminary study of detecting neoplastic growths in vivo with real time calibrated autofluorescence imaging

Tao Wu, Jianan Y. Qu, Tak-Hong Cheung, Keith Wing-Kit Lo, and Mei-Yung Yu  »View Author Affiliations

Optics Express, Vol. 11, Issue 4, pp. 291-298 (2003)

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The goal of this study was to evaluate the capabilities of a calibrated autofluorescence imaging method for detecting neoplastic lesions. An imaging system that records autofluorescence images calibrated by the cross-polarized reflection images from excitation was instrumented for the evaluation. Cervical tissue was selected as the living tissue model. Sixteen human subjects were examined in vivo with the imaging system before routine examination procedures. It was found that calibrated autofluorescence signals from neoplastic lesions were generally lower than signals from normal cervical tissue. Neoplastic lesions can be differentiated from surrounding normal tissue based on the contrast in the calibrated autofluorescence. The effects of the optical properties of tissue on the calibrated fluorescence imaging were investigated.

© 2003 Optical Society of America

OCIS Codes
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics

ToC Category:
Research Papers

Original Manuscript: January 17, 2003
Revised Manuscript: February 6, 2003
Published: February 24, 2003

Tao Wu, Jianan Qu, Tak-Hong Cheung, Keith Lo, and Mei-Yung Yu, "Preliminary study of detecting neoplastic growths in vivo with real time calibrated autofluorescence imaging," Opt. Express 11, 291-298 (2003)

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