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Optics Express

Optics Express

  • Editor: Michael Duncan
  • Vol. 11, Iss. 8 — Apr. 21, 2003
  • pp: 853–867

Use of a nonlinear perturbation approach for in vivo breast lesion characterization by multiwavelength time-resolved optical mammography

Alessandro Torricelli, Lorenzo Spinelli, Antonio Pifferi, Paola Taroni, Rinaldo Cubeddu, and Gian Maria Danesini  »View Author Affiliations


Optics Express, Vol. 11, Issue 8, pp. 853-867 (2003)
http://dx.doi.org/10.1364/OE.11.000853


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Abstract

A novel nonlinear perturbation model was successfully applied to the in vivo characterization of breast lesions (cysts and tumors) after detection by multi-wavelength time-resolved optical mammography. The model relies on the method of Padé approximants and consists in a nonlinear approximation of time-resolved transmittance curves in the presence of an inclusion. Tissue constituents (blood volume, blood oxygen saturation, lipids and water content) were estimated for both the bulk and the lesion areas. Cysts were reported to have high water content while tumors showed increased blood content as compared to bulk tissue.

© 2003 Optical Society of America

OCIS Codes
(170.3830) Medical optics and biotechnology : Mammography
(170.4730) Medical optics and biotechnology : Optical pathology
(170.5280) Medical optics and biotechnology : Photon migration
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(170.6920) Medical optics and biotechnology : Time-resolved imaging

ToC Category:
Research Papers

History
Original Manuscript: March 5, 2003
Revised Manuscript: April 1, 2003
Published: April 21, 2003

Citation
Alessandro Torricelli, Lorenzo Spinelli, Antonio Pifferi, Paola Taroni, Rinaldo Cubeddu, and Gian Danesini, "Use of a nonlinear perturbation approach for in vivo breast lesion characterization by multiwavelength time-resolved optical mammography," Opt. Express 11, 853-867 (2003)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-11-8-853


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