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Optics Express

Optics Express

  • Editor: Michael Duncan
  • Vol. 12, Iss. 11 — May. 31, 2004
  • pp: 2404–2422

Ultrahigh-resolution, high-speed, Fourier domain optical coherence tomography and methods for dispersion compensation

Maciej Wojtkowski, Vivek J. Srinivasan, Tony H. Ko, James G. Fujimoto, Andrzej Kowalczyk, and Jay S. Duker  »View Author Affiliations


Optics Express, Vol. 12, Issue 11, pp. 2404-2422 (2004)
http://dx.doi.org/10.1364/OPEX.12.002404


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Abstract

Ultrahigh-resolution optical coherence tomography uses broadband light sources to achieve axial image resolutions on the few micron scale. Fourier domain detection methods enable more than an order of magnitude increase in imaging speed and sensitivity, thus overcoming the sensitivity limitations inherent in ultrahigh-resolution OCT using standard time domain detection. Fourier domain methods also provide direct access to the spectrum of the optical signal. This enables automatic numerical dispersion compensation, a key factor in achieving ultrahigh image resolutions. We present ultrahigh-resolution, high-speed Fourier domain OCT imaging with an axial resolution of 2.1 µm in tissue and 16,000 axial scans per second at 1024 pixels per axial scan. Ultrahigh-resolution spectral domain OCT is shown to provide a ~100x increase in imaging speed when compared to ultrahigh-resolution time domain OCT. In vivo imaging of the human retina is demonstrated. We also present a general technique for automatic numerical dispersion compensation, which is applicable to spectral domain as well as swept source embodiments of Fourier domain OCT.

© 2004 Optical Society of America

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4500) Medical optics and biotechnology : Optical coherence tomography

ToC Category:
Research Papers

History
Original Manuscript: April 12, 2004
Revised Manuscript: May 10, 2004
Published: May 30, 2004

Citation
Maciej Wojtkowski, Vivek Srinivasan, Tony Ko, James Fujimoto, Andrzej Kowalczyk, and Jay Duker, "Ultrahigh-resolution, high-speed, Fourier domain optical coherence tomography and methods for dispersion compensation," Opt. Express 12, 2404-2422 (2004)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-12-11-2404


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