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Optics Express

Optics Express

  • Editor: Michael Duncan
  • Vol. 12, Iss. 17 — Aug. 23, 2004
  • pp: 3996–4000

Three-dimensional bioluminescence tomography with model-based reconstruction

Xuejun Gu, Qizhi Zhang, Lyndon Larcom, and Huabei Jiang  »View Author Affiliations

Optics Express, Vol. 12, Issue 17, pp. 3996-4000 (2004)

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A model-based image reconstruction method, bioluminescence tomography (BLT), is described. BLT has the potential to spatially resolve bioluminescence associated with gene expression in vivo, thus, offering a tomographic molecular imaging method. The three-dimensional spatial map of reporter genes is recovered using a diffusion equation model-based, finite element reconstruction algorithm. The imaging method is demonstrated using both numerical simulations and phantom experiments.

© 2004 Optical Society of America

OCIS Codes
(110.6960) Imaging systems : Tomography
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.6280) Medical optics and biotechnology : Spectroscopy, fluorescence and luminescence

ToC Category:
Research Papers

Original Manuscript: July 20, 2004
Revised Manuscript: August 9, 2004
Published: August 23, 2004

Xuejun Gu, Qizhi Zhang, Lyndon Larcom, and Huabei Jiang, "Three-dimensional bioluminescence tomography with model-based reconstruction," Opt. Express 12, 3996-4000 (2004)

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