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Optics Express

Optics Express

  • Editor: Michael Duncan
  • Vol. 12, Iss. 19 — Sep. 20, 2004
  • pp: 4353–4365

Quantitative measurement of attenuation coefficients of weakly scattering media using optical coherence tomography

Dirk J. Faber, Freek J. van der Meer, Maurice C.G. Aalders, and Ton G. van Leeuwen  »View Author Affiliations


Optics Express, Vol. 12, Issue 19, pp. 4353-4365 (2004)
http://dx.doi.org/10.1364/OPEX.12.004353


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Abstract

From calibrated, weakly scattering tissue phantoms (2–6 mm-1), we extract the attenuation coefficient with an accuracy of 0.8 mm-1 from OCT data in the clinically relevant ‘fixed focus’ geometry. The data are analyzed using a single scattering model and a recently developed description of the confocal point spread function (PSF). We verify the validity of the single scattering model by a quantitative comparison with a multiple scattering model, and validate the use of the PSF on the calibrated samples. Implementation of this model for existing OCT systems will be straightforward. Localized quantitative measurement of the attenuation coefficient of different tissues can significantly improve the clinical value of OCT.

© 2004 Optical Society of America

OCIS Codes
(110.4500) Imaging systems : Optical coherence tomography
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4500) Medical optics and biotechnology : Optical coherence tomography

ToC Category:
Research Papers

History
Original Manuscript: July 28, 2004
Revised Manuscript: August 30, 2004
Published: September 20, 2004

Citation
Dirk Faber, Freek van der Meer, Maurice Aalders, and Ton van Leeuwen, "Quantitative measurement of attenuation coefficients of weakly scattering media using optical coherence tomography," Opt. Express 12, 4353-4365 (2004)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-12-19-4353


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References

  1. D. Huang, E. A. Swanson, C.P. Lin, J.S. Schuman, W.G. Stinson, W. Chang, M.R. Hee, T. Flotte, K. Gregory, C.A. Puliafito, J.G. Fujimoto, �??Optical coherence tomography,�?? Science 254, 1178-1181 (1991). [CrossRef] [PubMed]
  2. N. Nassif, B. Cense, B.H. Park, S.H. Yun, T.C. Chen, B.E. Bouma, G.J. Tearney, J.F. de Boer, �??In vivo human retinal imaging by ultrahigh-speed spectral domain optical coherence tomography,�?? Opt. Lett, 29, 480-482 (2004). [CrossRef] [PubMed]
  3. A. Unterhuber, B. Povazay, B. Hermann, H. Sattmann, W. Drexler, V. Yakovlev, G. Tempea, C. Schubert, E. M. Anger, P. K. Ahnelt, M. Stur, J. E. Morgan, A. Cowey, G. Jung, T. Le, A. Stingl, �??Compact, low-cost TiAl 2 O 3 laser for in vivo ultrahigh-resolution optical coherence tomography,�?? Opt. Lett, 28, 905-907 (2003). [CrossRef]
  4. J. M. Schmitt, A. Knüttel, M. Yadlowsky, and M. A. Eckhaus, �??Optical-coherence tomography of a dense tissue: statistics of attenuation and backscattering,�?? Phys. Med. Biol. 39, 1705-1720 (1994). [CrossRef] [PubMed]
  5. R. O. Esenaliev, K. V. Larin, I. V. Larina, and M. Motamedi, �??Noninvasive monitoring of glucose concentration with optical coherence tomography,�?? Opt. Lett. 26, 992-994 (2001). [CrossRef]
  6. A.I. Kholodnykh, I.Y. Petrova, K.V. Larin, M. Motamedi, R.O. Esenaliev, �??Precision of Measurement of Tissue Optical Properties with Optical Coherence Tomography�??, Appl. Opt. 42, 3027-3037 (2003). [CrossRef] [PubMed]
  7. L. Thrane, H. T. Yura, and P. E. Andersen, �??Analysis of optical coherence tomography systems based on the extended HuygensFresnel principle,�?? J. Opt. Soc. Am. A 17, 484-490 (2000). [CrossRef]
  8. D. Levitz, L. Thrane, M.H. Frosz, P.E. Andersen, C.B. Andersen, S. Andersson-Engels, J. Valanciunaite, J. Swartling, P.R. Hansen, �??Determination of optical scattering properties of highly-scattering media in optical coherence tomography images,�?? Opt. Express 12, 249-259 (2004). [CrossRef] [PubMed]
  9. A. Knuettel, S. Bonev, W. Knaak, �??New method for evaluation of in vivo scattering and refractive index properties obtained with optical coherence tomography,�?? J. Biomed. Opt. 9, 232-273 (2004).
  10. J. A. Izatt, M.R. Hee, G.M. Owen, E.A. Swanson, J.G. ujimoto, �??Optical coherence microscopy in scattering media,�?? Opt. Lett. 19, 590-592 (1994). [CrossRef] [PubMed]
  11. A.I.Kholodnykh, I.Y. Petrova, M. Motamedi, R.O. Esenaliev, �??Accurate measurement of total attenuation coefficient of thin tissue with optical coherence tomography�??, IEEE J. Sel. Top. Quantum Electron. 9, 210- 221 (2003) [CrossRef]
  12. T.G. van Leeuwen, D.J. Faber, M.C. Aalders, IEEE J. Sel. Top. Quantum Electron. 9, 227-233 (2003). [CrossRef]
  13. W. H. Press, �??Numerical Recipes�?? (Cambridge University Press, Cambridge, 1986).
  14. D.G. Altman, �??Practical statistics for medical research�?? (Chapman&Hall, London, 1991).
  15. J. Swartling, J. S. Dam, and S. Andersson-Engels, �??Comparison of Spatially and Temporally Resolved Diffuse-Reflectance Measurement Systems for Determination of Biomedical Optical Properties�?? Appl. Opt. 42, 4612-4620 (2003). [CrossRef] [PubMed]
  16. G.A. Massey, A.E. Siegman, �??Reflection and refraction of Gaussian light beams at tilted ellipsoidal surfaces,�?? Appl. Opt. 8, 975-978 (1969) [CrossRef] [PubMed]
  17. J.M. Schmitt, A. Knüttel, R.F. Bonner, �??Measurement of optical properties of biological tissues by low-coherence reflectometry,�?? Appl. Opt 32(30), 6032. [PubMed]
  18. F.J. van der Meer, D.J. Faber, D.M. Baraznji Sassoon, M.C. Aalders, G. Pasterkamp, T.G. van Leeuwen, �??Localized measurement of optical attenuation coefficients of atherosclerotic plaque constituents by quantitative optical coherence tomography�??, submitted to IEEE transactions on Medical Imaging, 2004..

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