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Optics Express

Optics Express

  • Editor: Michael Duncan
  • Vol. 12, Iss. 19 — Sep. 20, 2004
  • pp: 4353–4365

Quantitative measurement of attenuation coefficients of weakly scattering media using optical coherence tomography

Dirk J. Faber, Freek J. van der Meer, Maurice C.G. Aalders, and Ton G. van Leeuwen  »View Author Affiliations

Optics Express, Vol. 12, Issue 19, pp. 4353-4365 (2004)

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From calibrated, weakly scattering tissue phantoms (2–6 mm-1), we extract the attenuation coefficient with an accuracy of 0.8 mm-1 from OCT data in the clinically relevant ‘fixed focus’ geometry. The data are analyzed using a single scattering model and a recently developed description of the confocal point spread function (PSF). We verify the validity of the single scattering model by a quantitative comparison with a multiple scattering model, and validate the use of the PSF on the calibrated samples. Implementation of this model for existing OCT systems will be straightforward. Localized quantitative measurement of the attenuation coefficient of different tissues can significantly improve the clinical value of OCT.

© 2004 Optical Society of America

OCIS Codes
(110.4500) Imaging systems : Optical coherence tomography
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4500) Medical optics and biotechnology : Optical coherence tomography

ToC Category:
Research Papers

Original Manuscript: July 28, 2004
Revised Manuscript: August 30, 2004
Published: September 20, 2004

Dirk Faber, Freek van der Meer, Maurice Aalders, and Ton van Leeuwen, "Quantitative measurement of attenuation coefficients of weakly scattering media using optical coherence tomography," Opt. Express 12, 4353-4365 (2004)

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