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Optics Express

Optics Express

  • Editor: Michael Duncan
  • Vol. 12, Iss. 19 — Sep. 20, 2004
  • pp: 4596–4601

Particle aggregation monitoring by speckle size measurement; application to blood platelets aggregation

Y. Piederriere, J. Le Meur, J. Cariou, J.F. Abgrall, and M.T. Blouch  »View Author Affiliations

Optics Express, Vol. 12, Issue 19, pp. 4596-4601 (2004)

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We report on a new method based on speckle size analysis and devoted to particle aggregation measurements. The experimental measurements give the speckle size variation during a salt aggregation process of polystyrene microspheres. The measurements are taken at a fixed monomer concentration, varying the salt concentration. Moreover, we applied this technique to follow blood platelet aggregation, usually monitored with a visible light transmittance photometer (aggregometer). Aggregation process was induced by ADP (adenosine diphosphate) addition, then we measured the speckle size variation versus time at two different ADP concentrations.

© 2004 Optical Society of America

OCIS Codes
(030.6140) Coherence and statistical optics : Speckle
(120.3890) Instrumentation, measurement, and metrology : Medical optics instrumentation
(170.1470) Medical optics and biotechnology : Blood or tissue constituent monitoring
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(290.5850) Scattering : Scattering, particles

ToC Category:
Research Papers

Original Manuscript: July 26, 2004
Revised Manuscript: August 23, 2004
Published: September 20, 2004

Yann Piederrière, J. Le Meur, J. Cariou, J. Abgrall, and M. Blouch, "Particle aggregation monitoring by speckle size measurement; application to blood platelets aggregation," Opt. Express 12, 4596-4601 (2004)

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