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Optics Express

Optics Express

  • Editor: Michael Duncan
  • Vol. 12, Iss. 2 — Jan. 26, 2004
  • pp: 249–259

Determination of optical scattering properties of highly-scattering media in optical coherence tomography images

David Levitz, Lars Thrane, Michael H. Frosz, Peter E. Andersen, Claus B. Andersen, Jurga Valanciunaite, Johannes Swartling, Stefan Andersson-Engels, and Peter R. Hansen  »View Author Affiliations

Optics Express, Vol. 12, Issue 2, pp. 249-259 (2004)

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We developed a new algorithm that fits optical coherence tomography (OCT) signals as a function of depth to a general theoretical OCT model which takes into account multiple scattering effects. With use of this algorithm, it was possible to extract both the scattering coefficient and anisotropy factor from a particular region of interest in an OCT image. The extraction algorithm was evaluated against measurements from an integrating sphere on a set of tissue phantoms and yielded valid results. Finally, a preliminary ex vivo OCT investigation on human aortic specimen indicated that the algorithm may contribute importantly to differentiation between normal and atherosclerotic arteries. We conclude that this algorithm may facilitate tissue characterization by OCT.

© 2004 Optical Society of America

OCIS Codes
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(290.0290) Scattering : Scattering

ToC Category:
Research Papers

Original Manuscript: November 14, 2003
Revised Manuscript: December 30, 2003
Published: January 26, 2004

David Levitz, Lars Thrane, Michael Frosz, Peter Andersen, Claus Andersen, Stefan Andersson-Engels, Jurga Valanciunaite, Johannes Swartling, and Peter Hansen, "Determination of optical scattering properties of highly-scattering media in optical coherence tomography images," Opt. Express 12, 249-259 (2004)

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