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Optics Express

Optics Express

  • Editor: Michael Duncan
  • Vol. 12, Iss. 20 — Oct. 4, 2004
  • pp: 4790–4803

Separation of absorption and scattering profiles in spectroscopic optical coherence tomography using a least-squares algorithm

Chenyang Xu, Daniel L. Marks, Minh N. Do, and Stephen A. Boppart  »View Author Affiliations

Optics Express, Vol. 12, Issue 20, pp. 4790-4803 (2004)

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In spectroscopic optical coherence tomography, it is important and useful to separately estimate the absorption and the scattering properties of tissue. In this paper, we propose a least-squares fitting algorithm to separate absorption and scattering profiles when near-infrared absorbing dyes are used. The algorithm utilizes the broadband Ti:sapphire laser spectrum together with joint time-frequency analysis. Noise contribution to the final estimation was analyzed using simulation. The validity of our algorithm was demonstrated using both single-layer and multi-layer tissue phantoms.

© 2004 Optical Society of America

OCIS Codes
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(290.0290) Scattering : Scattering
(290.7050) Scattering : Turbid media
(300.1030) Spectroscopy : Absorption
(300.6360) Spectroscopy : Spectroscopy, laser

ToC Category:
Research Papers

Original Manuscript: August 2, 2004
Revised Manuscript: September 16, 2004
Published: October 4, 2004

Chenyang Xu, Daniel Marks, Minh Do, and Stephen Boppart, "Separation of absorption and scattering profiles in spectroscopic optical coherence tomography using a least-squares algorithm," Opt. Express 12, 4790-4803 (2004)

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