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Optics Express

Optics Express

  • Editor: Michael Duncan
  • Vol. 12, Iss. 22 — Nov. 1, 2004
  • pp: 5487–5501

Optical coherence tomography contrast enhancement using spectroscopic analysis with spectral autocorrelation

Desmond C. Adler, Tony H. Ko, Paul R. Herz, and James G. Fujimoto  »View Author Affiliations


Optics Express, Vol. 12, Issue 22, pp. 5487-5501 (2004)
http://dx.doi.org/10.1364/OPEX.12.005487


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Abstract

Enhanced tissue contrast in developmental biology specimens is demonstrated in vivo using a new type of spectroscopic optical coherence tomography analysis that is insensitive to spectroscopic noise sources. The technique is based on a statistical analysis of spectral modulation at each image pixel, and provides contrast based on both the intensity of the backscattered light and the distribution of scattering particle sizes. Since the technique does not analyze optical power at absolute wavelengths, it is insensitive to all spectroscopic noise that appears as local Doppler shifts. No exogenous contrast agents or dyes are required, and no additional components are needed to correct for reference arm motion.

© 2004 Optical Society of America

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4500) Medical optics and biotechnology : Optical coherence tomography

ToC Category:
Research Papers

History
Original Manuscript: August 10, 2004
Revised Manuscript: September 11, 2004
Published: November 1, 2004

Citation
Desmond Adler, Tony Ko, Paul Herz, and James Fujimoto, "Optical coherence tomography contrast enhancement using spectroscopic analysis with spectral autocorrelation," Opt. Express 12, 5487-5501 (2004)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-12-22-5487


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