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Optics Express

Optics Express

  • Editor: Michael Duncan
  • Vol. 12, Iss. 8 — Apr. 19, 2004
  • pp: 1677–1688

Precision of extracting absorption profiles from weakly scattering media with spectroscopic time-domain optical coherence tomography

B. Hermann, K. Bizheva, A. Unterhuber, B. Považay, H. Sattmann, L. Schmetterer, A. F. Fercher, and W. Drexler  »View Author Affiliations

Optics Express, Vol. 12, Issue 8, pp. 1677-1688 (2004)

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The feasibility of spectroscopic optical coherence tomography (SOCT) to quantify spatially localized absorption profiles of chromophores embedded in weakly scattering media with a single measurement over the full spectral bandwidth of the light source was investigated by using a state-of-the-art ultra-broad bandwidth Ti:Al2O3 laser (λc =800 nm, Δλ=260 nm, Pout =120 mW ex-fiber). The precision of the method as a function of the chromophore absorption, the sample thickness, and different parameters related to the measurement procedure was evaluated both theoretically and experimentally in single and multilayered phantoms. It is demonstrated that in weakly scattering media SOCT is able to extract µa (λ) as small as 0.5 mm-1 from 450 µm thick phantoms with a precision of ~2% in the central and ~8% at the edges of the used wavelength region. As expected, in phantoms with the same absorption properties and thickness ~180 µm the precision of SOCT decreases to >10% in the central wavelength region.

© 2004 Optical Society of America

OCIS Codes
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(300.1030) Spectroscopy : Absorption
(300.6360) Spectroscopy : Spectroscopy, laser
(320.7090) Ultrafast optics : Ultrafast lasers

ToC Category:
Research Papers

Original Manuscript: March 15, 2004
Revised Manuscript: March 29, 2004
Published: April 19, 2004

B. Hermann, K. Bizheva, A. Unterhuber, B. Považay, H. Sattmann, L. Schmetterer, A. Fercher, and W. Drexler, "Precision of extracting absorption profiles from weakly scattering media with spectroscopic time-domain optical coherence tomography," Opt. Express 12, 1677-1688 (2004)

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