OSA's Digital Library

Optics Express

Optics Express

  • Editor: Michael Duncan
  • Vol. 13, Iss. 10 — May. 16, 2005
  • pp: 3681–3689

Full-field laser Doppler perfusion imaging and monitoring with an intelligent CMOS camera

Alexandre Serov, Beda Steinacher, and Theo Lasser  »View Author Affiliations

Optics Express, Vol. 13, Issue 10, pp. 3681-3689 (2005)

View Full Text Article

Enhanced HTML    Acrobat PDF (267 KB)

Browse Journals / Lookup Meetings

Browse by Journal and Year


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools



A system for full-field laser Doppler blood flow imaging has been developed and tested on biomedical samples. The new imaging system allows 2D flow maps or monitoring flux signals to be obtained from a plurality of measured points simultaneously by using a 2D array of photodetectors. The detection part of the system is based on an intelligent CMOS camera with a built-in digital signal processor and memory. The imaging time of the system is as much as to 4 times faster than for the conventional scanning laser Doppler imager. The performance of the system was evaluated in vitro and in vivo. The first measurement results with this new system on human skin are reported.

© 2005 Optical Society of America

OCIS Codes
(170.1650) Medical optics and biotechnology : Coherence imaging
(170.3340) Medical optics and biotechnology : Laser Doppler velocimetry
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine

ToC Category:
Research Papers

Original Manuscript: April 14, 2005
Revised Manuscript: April 29, 2005
Published: May 16, 2005

Alexandre Serov, Beda Steinacher, and Theo Lasser, "Full-field laser Doppler perfusion imaging and monitoring with an intelligent CMOS camera," Opt. Express 13, 3681-3689 (2005)

Sort:  Journal  |  Reset  


  1. A. P. Shepherd and P. �?. �?berg, Laser-Doppler Blood Flowmetry (Kluwer Academic, Boston, 1990).
  2. K.Wårdell, A.Jakobsson, and G .E. Nilsson, �??Laser Doppler perfusion imaging by dynamic light scattering,�?? IEEE Trans. Biomed. Eng. 40, 309-316 (1993). [CrossRef] [PubMed]
  3. T. J. H. Essex and P. O. Byrne, �??A laser Doppler scanner for imaging blood flow in skin,�?? J. Biomed. Eng. 13, 189-193 (1991). [CrossRef] [PubMed]
  4. H. Fujii, K. Nohira, Y. Yamamoto, H. Ikawa, and T. Ohura, �??Evaluation of blood flow by laser speckle image sensing. Part 1,�?? Appl. Opt. 26, 5321-5325 (1987). [CrossRef] [PubMed]
  5. J. D. Briers, G. Richards, and X. W. He, �??Capillary blood flow monitoring using laser speckle contrast analysis (LASCA),�?? J. Biomed. Opt. 4, 164-175 (1999). [CrossRef]
  6. J. D. Briers, �??Laser Doppler, speckle and related techniques for blood perfusion mapping and imaging,�?? Physiol. Meas. 22, R35-R66 (2001). [CrossRef]
  7. A. Serov, W. Steenbergen, and F. F. M. de Mul, �??Laser Doppler perfusion imaging with a complimentary metal oxide semiconductor image sensor,�?? Opt. Lett. 25, 300-302 (2002). [CrossRef]
  8. R.Bonner and R.Nossal, �??Model for laser Doppler measurements of blood flow in tissue,�?? Appl. Opt. 20, 2097-2107 (1981). [CrossRef]
  9. S. T. Flock, S. L. Jacques, B. C. Wilson, W. M. Star, and M. J. C. van Gemert, �??Optical properties of intralipid: a phantom medium for light propagation studies,�?? Lasers Surgery Med. 12, 510-519 (1992). [CrossRef]
  10. E. R. Fossum, �??CMOS image sensors: electronic camera-on-a-chip,�?? IEEE Trans. Electron Devices 44, 1698-1698 (1997). [CrossRef]
  11. A. Serov, W. Steenbergen, and F. F. M. de Mul, �??Prediction of the photodetector signal generated by Doppler-induced speckle fluctuations: theory and some validations,�?? J. Opt. Soc. Am. A 18, 622-630 (2001).

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited