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Optics Express

Optics Express

  • Editor: Michael Duncan
  • Vol. 13, Iss. 12 — Jun. 13, 2005
  • pp: 4465–4475

Investigation of bi-phasic tumor oxygen dynamics induced by hyperoxic gas intervention: A numerical study

Jae G. Kim and Hanli Liu  »View Author Affiliations

Optics Express, Vol. 13, Issue 12, pp. 4465-4475 (2005)

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This study intends to explore the underlying principle of the bi-phasic behavior of increases in oxygenated hemoglobin concentration that was observed in vivo from rat breast tumors during carbogen/oxygen inhalation. We have utilized the Finite Element Method (FEM) to simulate the effects of different blood flow rates, in several geometries, on the near infrared measurements. The results show clearly that co-existence of two blood flow velocities can result in a bi-phasic change in optical density, regardless of the orientation of vessels. This study supports our previous hypothesis that the bi-phasic tumor hemodynamic feature during carbogen inhalation results from a well-perfused and a poorly perfused region in the tumor vasculature.

© 2005 Optical Society of America

OCIS Codes
(000.4430) General : Numerical approximation and analysis
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.5280) Medical optics and biotechnology : Photon migration
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(290.1990) Scattering : Diffusion

ToC Category:
Research Papers

Original Manuscript: April 13, 2005
Revised Manuscript: May 23, 2005
Manuscript Accepted: May 30, 2005
Published: June 13, 2005

Jae G. Kim and Hanli Liu, "Investigation of bi-phasic tumor oxygen dynamics induced by hyperoxic gas intervention: A numerical study," Opt. Express 13, 4465-4475 (2005)

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