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Optics Express

Optics Express

  • Editor: Michael Duncan
  • Vol. 13, Iss. 12 — Jun. 13, 2005
  • pp: 4507–4518

Depth-resolved optic axis orientation in multiple layered anisotropic tissues measured with enhanced polarization-sensitive optical coherence tomography (EPS-OCT)

Nate J. Kemp, Haitham N. Zaatari, Jesung Park, H. Grady Rylander III, and Thomas E. Milner  »View Author Affiliations


Optics Express, Vol. 13, Issue 12, pp. 4507-4518 (2005)
http://dx.doi.org/10.1364/OPEX.13.004507


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Abstract

Enhanced polarization-sensitive optical coherence tomography (EPS-OCT) is a noninvasive cross-sectional imaging technique capable of quantifying with high sensitivity the optically anisotropic properties of fibrous tissues. We present a method to measure the depth-resolved optic axis orientations in superficial and deep regions of multiple-layered form-birefringent tissue. Additionally, the bulk-optic EPS-OCT instrument provides anatomical fiber direction referenced absolutely to the laboratory frame, in contrast with fiber-based PS-OCT instruments which provide relative optic axis orientation measurements. Results presented on ex vivo murine tail tendon and porcine annulus fibrosis indicate that the method is capable of characterizing depth-resolved fiber direction [θ(z)], form-birefringence [Δn(z)], and form-biattenuance [Δχ(z)] for at least 10 successive lamellae and a depth of 0.52 mm into the intervertebral disc. Noninvasive assessment of optic axis orientation by EPS-OCT provides increased contrast in images of multiple-layered media and may improve the understanding of fibrous tissue ultrastructure and the diseases or traumas that affect fibrous tissues.

© 2005 Optical Society of America

OCIS Codes
(030.6140) Coherence and statistical optics : Speckle
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(260.1440) Physical optics : Birefringence
(260.5430) Physical optics : Polarization

ToC Category:
Research Papers

History
Original Manuscript: April 26, 2005
Revised Manuscript: May 23, 2005
Published: June 13, 2005

Citation
Nate Kemp, Haitham Zaatari, Jesung Park, H. Grady Rylander III, and Thomas Milner, "Depth-resolved optic axis orientation in multiple layered anisotropic tissues measured with enhanced polarization-sensitive optical coherence tomography (EPS-OCT)," Opt. Express 13, 4507-4518 (2005)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-13-12-4507


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