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Optics Express

Optics Express

  • Editor: Michael Duncan
  • Vol. 13, Iss. 12 — Jun. 13, 2005
  • pp: 4525–4538

New multichannel near infrared spectrophotometry system for functional studies of the brain in adults and neonates

Daniel Haensse, Peter Szabo, Derek Brown, Jean-Claude Fauchère, Peter Niederer, Hans-Ulrich Bucher, and Martin Wolfa  »View Author Affiliations


Optics Express, Vol. 13, Issue 12, pp. 4525-4538 (2005)
http://dx.doi.org/10.1364/OPEX.13.004525


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Abstract

We have designed a versatile, multi-channel near-infrared spectrophotometry (NIRS) instrument for the purpose of mapping neuronal activation in the neonatal and adult brain in response to motor, tactile, and visual stimulation. The optical linearity, stability, and high signal to noise ratio (>70 dB) of the instrument were demonstrated using an in vitro validation procedure. In vivo measurements on the adult forearm were also performed. Changes in oxygenation, induced by arterial occlusion of the forearm, were recorded and were shown to compare well with measurements acquired using a conventional NIRS instrument. To demonstrate the capabilities of the instrument, functional measurements in adults and neonates were performed. The instrument exhibited the capability to differentiate with a spatial resolution in the order of cm, local activation patterns associated with a finger tapping sequence.

© 2005 Optical Society of America

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.6920) Medical optics and biotechnology : Time-resolved imaging
(250.3140) Optoelectronics : Integrated optoelectronic circuits

ToC Category:
Research Papers

History
Original Manuscript: April 14, 2005
Revised Manuscript: May 25, 2005
Published: June 13, 2005

Citation
Daniel Haensse, Peter Szabo, Derek Brown, Jean-Claude Fauchère, Peter Niederer, Hans-Ulrich Bucher, and Martin Wolf, "A new multichannel near infrared spectrophotometry system for functional studies of the brain in adults and neonates," Opt. Express 13, 4525-4538 (2005)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-13-12-4525


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