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Optics Express

Optics Express

  • Editor: Michael Duncan
  • Vol. 13, Iss. 14 — Jul. 11, 2005
  • pp: 5205–5215

Terahertz time-domain spectroscopy and imaging of artificial RNA

Bernd M. Fischer, Matthias Hoffmann, Hanspeter Helm, Rafal Wilk, Frank Rutz, Thomas Kleine-Ostmann, Martin Koch, and Peter Uhd Jepsen  »View Author Affiliations

Optics Express, Vol. 13, Issue 14, pp. 5205-5215 (2005)

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We use terahertz time-domain spectroscopy (THz-TDS) to measure the far-infrared dielectric function of two artificial RNA single strands, composed of polyadenylic acid (poly-A) and polycytidylic acid (poly-C). We find a significant difference in the absorption between the two types of RNA strands, and we show that we can use this difference to record images of spot arrays of the RNA strands. Under controlled conditions it is possible to use the THz image to distinguish between the two RNA strands. We discuss the requirements to sample preparation imposed by the lack of sharp spectral features in the absorption spectra.

© 2005 Optical Society of America

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(300.6270) Spectroscopy : Spectroscopy, far infrared

ToC Category:
Research Papers

Original Manuscript: April 15, 2005
Revised Manuscript: June 14, 2005
Published: July 11, 2005

Bernd Fischer, Matthias Hoffmann, Hanspeter Helm, Rafal Wilk, Frank Rutz, Thomas Kleine-Ostmann, Martin Koch, and Peter Jepsen, "Terahertz time-domain spectroscopy and imaging of artificial RNA," Opt. Express 13, 5205-5215 (2005)

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