OSA's Digital Library

Optics Express

Optics Express

  • Editor: Michael Duncan
  • Vol. 13, Iss. 14 — Jul. 11, 2005
  • pp: 5450–5462

Wavelength-dependent scattering in spectroscopic optical coherence tomography

Chenyang Xu, P. Scott Carney, and Stephen A. Boppart  »View Author Affiliations


Optics Express, Vol. 13, Issue 14, pp. 5450-5462 (2005)
http://dx.doi.org/10.1364/OPEX.13.005450


View Full Text Article

Enhanced HTML    Acrobat PDF (577 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

The particle sizing capabilities of light scattering spectroscopy (LSS) and the spatial localization of optical coherence tomography (OCT) are brought together in a new modality known as scattering-mode spectroscopic OCT. An analysis is presented of the spectral dependence of the light collected in spectroscopic OCT for samples comprised of spherical particles. Many factors are considered including the effects of scatterer size, interference between the fields scattered from closely adjacent scatterers, and the numerical aperture of the OCT system. The modulation of the spectrum of the incident light by scattering of a plane wave from a single sphere is a good indicator of particle size and composition. However, it is shown in this work that the sharp focusing of fields causes the spectral signature to shift and the presence of multiple scatterers has dramatic modulation effects on the spectra. Approaches for accurately matching physical structure with the observed signals under various conditions are discussed.

© 2005 Optical Society of America

OCIS Codes
(110.4500) Imaging systems : Optical coherence tomography
(290.0290) Scattering : Scattering
(300.0300) Spectroscopy : Spectroscopy

ToC Category:
Research Papers

History
Original Manuscript: June 2, 2005
Revised Manuscript: June 26, 2005
Published: July 11, 2005

Citation
Chenyang Xu, P. Carney, and Stephen Boppart, "Wavelength-dependent scattering in spectroscopic optical coherence tomography," Opt. Express 13, 5450-5462 (2005)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-13-14-5450


Sort:  Journal  |  Reset  

References

  1. A. Ben-Reuven and N. D. Gershon, "Light scattering by orientational fluctuations in liquids," J. Chem. Phys. 51, 893-902 (1969). [CrossRef]
  2. S. R. Aragon and E. Pecora, "Theory of dynamic light scattering from large anisotropic particles," J. Chem. Phys. 66, 2506-2516 (1977). [CrossRef]
  3. V. Backman, M. B. Wallace, L. T. Perelman, J. T. Arendt, R. Gurjar, M. G. Muller, Q. Zhang, G. Zonios, E. Kline, T. Mcgillican, S. Shapshay, T. Valdez, K. Badizadegan, J. M. Crawford, M. Fitzmaurice, S. Kabani, H. S. Levin, M. Seiler, R. R. Dasari, I. Itzkan, J. Van Dam, and M. S. Feld, "Detection of preinvasive cancer cells," Nature 406, 35-36 (2000). [CrossRef] [PubMed]
  4. N. N. Boustany, S. C. Kuo, and N. V. Thakor, "Optical scatter imaging: subcellular morphometry in situ with Fourier filtering," Opt. Lett. 26, 1063-1065 (2001). [CrossRef]
  5. J. R. Mourant, "Spectroscopic diagnosis of bladder cancer with elastic light scattering," Laser Surgical Medicine 17, 350-357 (1995). [CrossRef]
  6. C. Yang, L. T. Perelman, A. Wax, R. R. Dasari, and M. S. Feld, "Feasibility of field-based light scattering spectroscopy," J. Biomed. Opt. 5, 138-143 (2000). [CrossRef] [PubMed]
  7. A. Wax, C. Yang, and J. A. Izatt, "Fourier-domain low-coherence interferometry for light-scattering spectroscopy," Opt. Lett. 28, 1230-1232 (2003). [CrossRef] [PubMed]
  8. J. W. Pyhtila, R. N. Graf, and A. Wax, "Determining nuclear morphology using an improved angle-resolved low coherence interferometry system," Opt. Express 11, 3473-3484 (2003). [CrossRef] [PubMed]
  9. J. W. Pyhtila and A. Wax, "Rapid, depth-resolved light scattering measurements using Fourier domain, angle-resolved low coherence interferometry," Opt. Express 12, 6178-6183 (2004). [CrossRef]
  10. D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography," Science 254, 1178-1181 (1991). [CrossRef] [PubMed]
  11. A. F. Fercher, W. Drexler, C. K. Hitzenberger, and T. Lasser, "Optical coherence tomography �?? principles and applications," Rep. Prog. Phys. 66, 239-303 (2003). [CrossRef]
  12. U. Morgner, W. Drexler, F. C. Kartner, X. D. Li, C. Pitris, E. P. Ippen, and J. G. Fujimoto, "Spectroscopic optical coherence tomography," Opt. Lett. 25, 111-113 (2000). [CrossRef]
  13. R. Leitgeb, M. Wojtkowski, A. Kowalczyk, C. K. Hitzenberger, M. Sticker, and A. F. Fercher, "Spectral measurement of absorption by spectroscopic frequency-domain optical coherence tomography," Opt. Lett. 25, 820-822 (2000). [CrossRef]
  14. D. J. Faber, E. G. Mik, M. C. G. Aalders, and L. T. G. V., "Light absorption of (oxy)hemoglobin assessed by spectroscopic optical coherence tomography," Opt. Lett. 28, 1436-1438 (2003). [CrossRef] [PubMed]
  15. C. Xu, J. Ye, D. L. Marks, and S. A. Boppart, "Near-infrared dyes as contrast-enhancing agents for spectroscopic optical coherence tomography," Opt. Lett. 29, 1647-1649 (2004). [CrossRef] [PubMed]
  16. B. Hermann, K. Bizheva, A. Unterhuber, B. Povazay, H. Sattmann, L. Schmetterer, A. F. Fercher, and W. Drexler, "Precision of extracting absorption profiles from weakly scattering media with spectroscopic time-domain optical coherence tomography," Opt. Express 12, 1677-1688 (2004). [CrossRef] [PubMed]
  17. R. Gurjar, V. Backman, J. M. Peralta, I. Georgakoudi, K. Badizadegan, I. Itzkan, R. R. Dasari, and M. S. Feld, "Imaging human epithelial properties with polarized light-scattering spectroscopy," Nature Medicine 7, 1245-1248 (2001). [CrossRef] [PubMed]
  18. T. H. Ko, D. C. Adler, J. G. Fujimoto, D. Mamedov, V. Prokhorov, V. Shidlovski, and S. Yakubovich, "Ultrahigh resolution optical coherence tomography imaging with a broadband superluminescent diode light source," Opt. Express 12, 2112-2119 (2004). [CrossRef] [PubMed]
  19. A. Dubois, G. Moneron, K. Grieve, and A. C. Boccara, "Three-dimensional cellular-level imaging using full-field optical coherence tomography," Phys. Med. and Biol. 49, 1227-1234 (2004). [CrossRef]
  20. C. Xu, F. Kamalabadi, and S. A. Boppart, "Comparative performance analysis of time-frequency distributions for spectroscopic optical coherence tomography," Appl. Opt. 44, 1813-1822 (2005). [CrossRef] [PubMed]
  21. C. Xu, D. L. Marks, M. N. Do, and S. A. Boppart, "Separation of absorption and scattering profiles in spectroscopic optical coherence tomography using a least-squares algorithm," Opt. Express 12, 4790-4803 (2004). [CrossRef] [PubMed]
  22. P. S. Carney, V. A. Markel, and J. C. Schotland, "Near-field tomography without phase retrieval," Phys. Rev. Lett. 86, 5874-5877 (2001). [CrossRef] [PubMed]
  23. A. Wax, C. Yang, V. Backman, K. Badizadegan, C. W. Boone, R. R. Dasari, and M. S. Feld, "Cell organization and substructure measured using angle-resolved low coherence interferometry," Biophys. J. 82, 2256-2264 (2002). [CrossRef] [PubMed]
  24. D. C. Adler, T. H. Ko, P. R. Herz, and J. G. Fujimoto, "Optical coherenece tomography contrast enhancement using spectroscopic analysis with spectral autocorrelation," Opt. Express 12, 5487-5501 (2004). [CrossRef] [PubMed]
  25. J. M. Schmitt, S. H. Xiang, and K. M. Yung, "Speckle in optical coherence tomography," J. Biomed. Opt. 4, 95-105 (1999). [CrossRef]
  26. L. T. Perelman, V. Backman, M. Wallace, G. Zonios, R. Manoharan, A. Nusrat, S. Schields, M. Seiler, C. Lima, T. Hamano, I. Itzkan, J. Van Dam, J. M. Crawford, and M. S. Feld, "Observation of periodic fine structure in reflectance from biological tissue: A new technique for measuring nuclear size distribution," Phys. Rev. Lett. 80, 627-630 (1998).

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.


« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited