OSA's Digital Library

Optics Express

Optics Express

  • Editor: Michael Duncan
  • Vol. 13, Iss. 14 — Jul. 11, 2005
  • pp: 5513–5521

Simultaneous integrated diffuse optical tomography and functional magnetic resonance imaging of the human brain

Xiaofeng Zhang, Vladislav Y. Toronov, and Andrew G. Webb  »View Author Affiliations


Optics Express, Vol. 13, Issue 14, pp. 5513-5521 (2005)
http://dx.doi.org/10.1364/OPEX.13.005513


View Full Text Article

Enhanced HTML    Acrobat PDF (291 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

A complete methodology has been developed to integrate simultaneous diffuse optical tomography (DOT) and functional magnetic resonance imaging (MRI) measurements. This includes development of an MRI-compatible optical probe and a method for accurate estimation of the positions of the source and detector optodes in the presence of subject-specific geometric deformations of the optical probe. Subject-specific head models are generated by segmentation of structural MR images. DOT image reconstruction involves solution of the forward problem of light transport in the head using Monte Carlo simulations, and inversion of the linearized problem for small perturbations of the absorption coefficient. Initial results show good co-localization between the DOT images of changes in oxy- and deoxyhemoglobin concentration and functional MRI data.

© 2005 Optical Society of America

OCIS Codes
(000.1430) General : Biology and medicine
(110.2350) Imaging systems : Fiber optics imaging
(170.3010) Medical optics and biotechnology : Image reconstruction techniques

ToC Category:
Research Papers

History
Original Manuscript: May 6, 2005
Revised Manuscript: June 2, 2005
Published: July 11, 2005

Citation
Xiaofeng Zhang, Vladislav Toronov, and Andrew Webb, "Simultaneous integrated diffuse optical tomography and functional magnetic resonance imaging of the human brain," Opt. Express 13, 5513-5521 (2005)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-13-14-5513


Sort:  Journal  |  Reset  

References

  1. M. Cutler, �??Transillumination as an aid in the diagnosis of breast lesion,�?? Surg. Gynecol. Obstet. 48, 721- 730 (1929).
  2. S. R. Arridge, �??Optical tomography in medical imaging,�?? Inverse Problems 15, R1-R53 (1999). [CrossRef]
  3. S. R. Arridge, M. Cope, P. van der Zee, P. J. Hillson, and D. T. Delpy, �??Visualization of the oxygenation state of the brain and muscle in newborn infants by near infrared transillumination, in: Information Processing in Medical Imaging,�?? S. L. Bacharach, ed., Martinus Nijholff Ltd (1986).
  4. P. Van der Zee and D.T. Delpy, "Simulation of the point spread function for light in tissue by a Monte Carlo method," Adv. Exp. Med. Biol. 215:179-91 (1987) [PubMed]
  5. P. Rolfe,�??In vivo near-infrared spectroscopy,�?? Ann. Rev. Biomed. Eng. 2, 715-54 (2000). [CrossRef]
  6. Y. Hoshi, I. Oda, Y. Wada, Y. Ito, Y. Yamashita, M. Oda, K. Ohta, Y. Yamada, and T. Mamoru, �??Visuospatial imagery is a fruitful strategy for the digit span backward task: a study with near-infrared optical tomography,�?? Brain. Res. Cogn. Brain. Res. 9(3), 339-342 (2000). [CrossRef]
  7. H. Obrig and A. Villringer, �??Beyond the visible-imaging the human brain with light,�?? J. Cereb. Blood Flow Metab. 23, 1-18 (2003). [CrossRef]
  8. A. Villringer and B. Chance, �??Non-invasive optical spectroscopy and imaging of human brain function,�?? Trends Neurosci. 20, 435-42 (1997). [CrossRef] [PubMed]
  9. D. A. Boas, A. M. Dale and M. A. Franceschini, �??Diffuse optical imaging of brain activation: approaches to optimizing image sensitivity, resolution, and accuracy,�?? Neuroimage 23, S275-288 (2004). [CrossRef] [PubMed]
  10. M. A. Franceschini and D. A. Boas, �??Noninvasive measurement of neuronal activity with near-infrared optical imaging,�?? Neuroimage 21, 372-386 (2004). [CrossRef] [PubMed]
  11. D. A. Boas and A. M. Dale, �??Simulation study of magnetic resonance imaging-guided cortically constrained diffuse optical tomography of human brain function,�?? Appl. Opt. 44, 1957-68 (2005). [CrossRef] [PubMed]
  12. B. J. MacIntosh, L. M. Klassen, and R. S. Menon, �??Transient hemodynamics during a breath hold challenge in a two part functional imaging study with simultaneous near-infrared spectroscopy in adult humans,�?? Neuroimage 20, 1246-52 (2003). [CrossRef] [PubMed]
  13. A. Kleinschmidt, H. Obrig, M. Requardt, K. D. Merboldt, U. Dirnagl, A. Villringer, and J. Frahm, �??Simultaneous recording of cerebral blood oxygenation changes during human brain activation by magnetic resonance imaging and near-infrared spectroscopy,�?? J. Cereb. Blood Flow Metab. 16, 817�??826 (1996). [CrossRef] [PubMed]
  14. G. Strangman, J. P. Culver, J. H. Thompson, and D. A.Boas, �??A quantitative comparison of simultaneous BOLD fMRI and NIRS recording during functional brain activation,�?? Neuroimage, 17, 719-731 (2002). [CrossRef] [PubMed]
  15. V. Toronov, A. Webb, J. H. Choi, M. Wolf, L. Safanova, U. Wolf and E. Gratton, �??Study of local cerebral hemodynamic fluctuations by simultaneous frequency-domain near-infrared spectroscopy and fMRI,�?? Optics Express 9(8), 417-326 (2001), <a href="http://www.opticsexpress.org/abstract.cfm?URI=OPEX-9-8-417">http://www.opticsexpress.org/abstract.cfm?URI=OPEX-9-8-417</a>. [CrossRef]
  16. V. Toronov, S. Walker, R. Gupta, J. H. Choi, E. Gratton, D. Hueber, and A. G. Webb, �??The roles of changes in deoxyhemoglobin concentration and regional cerebral blood volume in the fMRI BOLD signal,�?? Neuroimage 19, 1521-31 (2003). [CrossRef] [PubMed]
  17. M. Wolf, U. Wolf, J. H. Choi, V. Toronov, L.A. Paunescu, A. Michalos, and E. Gratton., �??Fast cerebral functional signal in the 100-ms range detected in the visual cortex by frequency-domain near-infrared spectrophotometry,�?? Psychophysiology 40(4):521-8 (2003). [CrossRef]
  18. R. Araki and I. Nashimoto, �??Near-infrared imaging in vivo (I): Image restoration technique applicable to the NIR projection images,�?? Adv. Exp. Med. Biol. 316, 155-61 (1992). [CrossRef] [PubMed]
  19. R. Araki and I. Nashimoto, �??Near-infrared imaging in vivo (II): Image restoration technique applicable to the NIR projection images,�?? Adv. Exp. Med. Biol. 316, 173-8 (1992). [CrossRef] [PubMed]
  20. V.Toronov, A.Webb, J. H. Choi, M. Wolf, A. Michalos, E. Gratton and D. Hueber, �??Investigation of human brain hemodynamics by simultaneous near-infrared spectroscopy and functional magnetic resonance imaging,�?? Med. Phys. 24, 521-527, (2001). [CrossRef]
  21. A. Maki, Y. Yamashita, Y. Ito, E. Watanabe, Y. Mayanagi, and H. Koizumi, �??Spatial and temporal analysis of human motor activity using noninvasive NIR topography,�?? Med. Phys. 22, 1997-2005 (1995). [CrossRef] [PubMed]
  22. C. Hirth, K. Villringer, A. Thiel, J. Bernarding, W. Muhlnickl, H. Obrig, U. Dirnagl, and A. Villringer, �??Towards brain mapping combining near-infrared spectroscopy and high resolution 3D MRI,�?? Adv. Exp. Med. Biol. 413, 139-47 (1997). [PubMed]
  23. M. Patterson, B. Chance, and B. Wilson, �??Time resolved reectance and transmittance for the non-invasive measurement of tissue optical properties,�?? Appl. Optics 28, 2331-2336 (1988). [CrossRef]
  24. M. Wolf, M. Keel, V. Dietz, K. von Siebenthal, H.U. Bucher, and O. Baenziger, �??The influence of a clear layer on near-infrared spectrophotometry measurements using a liquid neonatal head phantom,�?? Phys. Med. Biol. 44, 1743-53 (1999). [CrossRef] [PubMed]
  25. D. A. Boas, J. P. Culver, J. J. Stott, and A. K. Dunn, �??Three dimensional Monte Carlo code for photon migration through complex heterogeneous media including the adult human head,�?? Optics Express, 10, 159-170 (2002), <a href="http://www.opticsexpress.org/abstract.cfm?URI=OPEX-10-3-159">http://www.opticsexpress.org/abstract.cfm?URI=OPEX-10-3-159</a>. [PubMed]
  26. A. Dunn and D. Boas, �??Transport-based image reconstruction in turbid media with small source detector separations,�?? Optics Letters 25, 1777-1779 (2000). [CrossRef]
  27. S. Fantini, M. A. Franceschini, and E. Gratton, �??Semi-infinite-geometry boundary problem for light migration in highly scattering media: a frequency-domain study in the diffusion approximation,�?? J. Opt. Soc. Am. B 11, 2128-38 (1994). [CrossRef]
  28. P. Bandettini, A. Jesmanowicz, E. Wong, and J. Hyde, �??Processing strategies for time-course data sets in functional MRI of the human brain,�?? Magn. Reson. Med. 30, 161-173 (1993). [CrossRef] [PubMed]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.

Figures

Fig. 1. Fig. 2. Fig. 3.
 

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited