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Optics Express

Optics Express

  • Editor: Michael Duncan
  • Vol. 13, Iss. 17 — Aug. 22, 2005
  • pp: 6416–6428

High-speed laser Doppler perfusion imaging using an integrating CMOS image sensor

Alexandre Serov and Theo Lasser  »View Author Affiliations

Optics Express, Vol. 13, Issue 17, pp. 6416-6428 (2005)

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This paper describes the design and the performance of a new high-speed laser Doppler imaging system for monitoring blood flow over an area of tissue. The new imager delivers high-resolution flow images (256×256 pixels) every 2 to 10 seconds, depending on the number of points in the acquired time-domain signal (32–512 points). This new imaging modality utilizes a digital integrating CMOS image sensor to detect Doppler signals in a plurality of points over the area illuminated by a divergent laser beam of a uniform intensity profile. The integrating property of the detector improves the signal-to-noise ratio of the measurements, which results in high-quality flow images. We made a series of measurements in vitro to test the performance of the system in terms of bandwidth, SNR, etc. Subsequently we give some examples of flow-related images measured on human skin, thus demonstrating the performance of the imager in vivo. The perspectives for future implementations of the imager for clinical and physiological applications are discussed.

© 2005 Optical Society of America

OCIS Codes
(170.1650) Medical optics and biotechnology : Coherence imaging
(170.3340) Medical optics and biotechnology : Laser Doppler velocimetry
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine

ToC Category:
Research Papers

Original Manuscript: July 8, 2005
Revised Manuscript: August 3, 2005
Published: August 22, 2005

Alexandre Serov and Theo Lasser, "High-speed laser Doppler perfusion imaging using an integrating CMOS image sensor," Opt. Express 13, 6416-6428 (2005)

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