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Optics Express

Optics Express

  • Editor: Michael Duncan
  • Vol. 13, Iss. 17 — Aug. 22, 2005
  • pp: 6416–6428

High-speed laser Doppler perfusion imaging using an integrating CMOS image sensor

Alexandre Serov and Theo Lasser  »View Author Affiliations


Optics Express, Vol. 13, Issue 17, pp. 6416-6428 (2005)
http://dx.doi.org/10.1364/OPEX.13.006416


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Abstract

This paper describes the design and the performance of a new high-speed laser Doppler imaging system for monitoring blood flow over an area of tissue. The new imager delivers high-resolution flow images (256×256 pixels) every 2 to 10 seconds, depending on the number of points in the acquired time-domain signal (32–512 points). This new imaging modality utilizes a digital integrating CMOS image sensor to detect Doppler signals in a plurality of points over the area illuminated by a divergent laser beam of a uniform intensity profile. The integrating property of the detector improves the signal-to-noise ratio of the measurements, which results in high-quality flow images. We made a series of measurements in vitro to test the performance of the system in terms of bandwidth, SNR, etc. Subsequently we give some examples of flow-related images measured on human skin, thus demonstrating the performance of the imager in vivo. The perspectives for future implementations of the imager for clinical and physiological applications are discussed.

© 2005 Optical Society of America

OCIS Codes
(170.1650) Medical optics and biotechnology : Coherence imaging
(170.3340) Medical optics and biotechnology : Laser Doppler velocimetry
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine

ToC Category:
Research Papers

History
Original Manuscript: July 8, 2005
Revised Manuscript: August 3, 2005
Published: August 22, 2005

Citation
Alexandre Serov and Theo Lasser, "High-speed laser Doppler perfusion imaging using an integrating CMOS image sensor," Opt. Express 13, 6416-6428 (2005)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-13-17-6416


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References

  1. G.V. Belcaro, U. Hoffman, A. Bollinger, and A.N. Nicolaides, Laser Doppler (Med-Orion Publishing Company, London, 1994).
  2. K. Wårdell, A. Jakobsson and G.E. Nilsson, �??Laser Doppler perfusion imaging by dynamic light scattering,�?? IEEE Trans. Biomed. Eng. 40, 309-316 (1993). [CrossRef] [PubMed]
  3. T.J.H. Essex and P.O. Byrne, �??A laser Doppler scanner for imaging blood flow in skin,�?? J. Biomed. Eng. 13, 189-193 (1991). [CrossRef] [PubMed]
  4. H. Fujii, K. Nohira, Y. Yamamoto, H. Ikawa, and T. Ohura, �??Evaluation of blood flow by laser speckle image sensing. Part 1,�?? Appl. Opt. 26, 5321-5325 (1987). [CrossRef] [PubMed]
  5. J.D. Briers, G. Richards, and X.W. He, �??Capillary blood flow monitoring using laser speckle contrast analysis (LASCA),�?? J. Biomed. Opt. 4, 164-175 (1999). [CrossRef]
  6. K.R. Forrester, J. Tulip, C. Leonard, C. Stewart, R.C. Bray, �??A laser speckle imaging technique for measuring tissue perfusion,�?? IEEE Trans. Biomed. Eng. 51, 2074-2084 (2004). [CrossRef] [PubMed]
  7. J.D. Briers, �??Laser Doppler, speckle and related techniques for blood perfusion mapping and imaging,�?? Physiol. Meas. 22, R35-R66 (2001). [CrossRef]
  8. A. Serov, W. Steenbergen, F.F.M. de Mul, �??Laser Doppler perfusion imaging with a complimentary metal oxide semiconductor image sensor,�?? Opt. Lett. 25, 300-302 (2002). [CrossRef]
  9. A. Serov, B. Steinacher, T. Lasser, �??Full-field laser Doppler perfusion imaging and monitoring with an intelligent CMOS camera,�?? Optics Express 13, 3681-3689 (2005), <a href= "http://www.opticsexpress.org/abstract.cfm?URI=OPEX-13-10-3681">http://www.opticsexpress.org/abstract.cfm?URI=OPEX-13-10-3681</a>. [CrossRef] [PubMed]
  10. R.H. Webb and G.W. Hughes, �??Detectors for scanning video imagers,�?? Appl. Opt. 32, 6227-6235 (1993). [CrossRef] [PubMed]
  11. A.N. Serov, W. Steenbergen and F. de Mul, �??Prediction of the photodetector signal generated by Doppler-induced speckle fluctuations: theory and some validations,�?? J. Opt. Soc. Am. A, 18, 622-639 (2001). [CrossRef]
  12. G.W. Anderson, B.D. Guenther, J.A. Hynecek, R.J. Keyes, and A. VanderLugt, �??Role of photodetectors in optical signal processing,�?? Appl. Opt. 27, 2871-2886 (1988). [CrossRef] [PubMed]
  13. M.H. White, D.R. Lampe, F.C. Blaha, and I.A. Mack, �??Characterization of surface channel CCD image arrays at low light levels,�?? IEEE J. Solid-State Circuits SC-9, 1-12 (1974). [CrossRef]
  14. R. Bonner and R. Nossal, �??Model for laser Doppler measurements of blood flow in tissue,�?? Appl. Opt. 20, 2097-2107 (1981). [CrossRef] [PubMed]

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