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Optics Express

Optics Express

  • Editor: Michael Duncan
  • Vol. 13, Iss. 17 — Aug. 22, 2005
  • pp: 6597–6614

Magnetomotive contrast for in vivo optical coherence tomography

Amy L. Oldenburg, Farah Jean-Jacques Toublan, Kenneth S. Suslick, Alexander Wei, and Stephen A. Boppart  »View Author Affiliations


Optics Express, Vol. 13, Issue 17, pp. 6597-6614 (2005)
http://dx.doi.org/10.1364/OPEX.13.006597


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Abstract

Molecularly-specific contrast can greatly enhance the biomedical utility of optical coherence tomography (OCT). We describe a contrast mechanism, magnetomotive OCT (MMOCT), where a modulated magnetic field induces motion of magnetic nanoparticles. The motion of the nanoparticles modifies the amplitude of the OCT interferogram. High specificity is achieved by subtracting the background fluctuations of the specimen, and sensitivity to 220 μg/g magnetite nanoparticles is demonstrated. Optically and mechanically correct tissue phantoms elucidate the relationships between imaging contrast and nanoparticle concentration, imaging depth, tissue optical scattering, and magnetic field strength. MMOCT is demonstrated in a living Xenopus laevis tadpole where the results were consistent with corresponding histology.

© 2005 Optical Society of America

OCIS Codes
(160.3820) Materials : Magneto-optical materials
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(290.5850) Scattering : Scattering, particles

ToC Category:
Research Papers

History
Original Manuscript: July 6, 2005
Revised Manuscript: August 15, 2005
Published: August 22, 2005

Citation
Amy Oldenburg, Farah Toublan, Kenneth Suslick, Alexander Wei, and Stephen Boppart, "Magnetomotive contrast for in vivo optical coherence tomography," Opt. Express 13, 6597-6614 (2005)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-13-17-6597


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