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Optics Express

Optics Express

  • Editor: Michael Duncan
  • Vol. 13, Iss. 2 — Jan. 24, 2005
  • pp: 410–416

Frequency estimation precision in Doppler optical coherence tomography using the Cramer-Rao lower bound

Siavash Yazdanfar, Changhuei Yang, Marinko V. Sarunic, and Joseph A. Izatt  »View Author Affiliations


Optics Express, Vol. 13, Issue 2, pp. 410-416 (2005)
http://dx.doi.org/10.1364/OPEX.13.000410


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Abstract

Doppler optical coherence tomography (DOCT) is a technique for simultaneous cross-sectional imaging of tissue structure and blood flow. We derive the fundamental uncertainty limits on frequency estimation precision in DOCT using the Cramer-Rao lower bound in the case of additive (e.g., thermal, shot) noise. Experimental results from a mirror and a scattering phantom are used to verify the theoretical limits. Our results demonstrate that the stochastic nature of frequency noise influences the precision of flow imaging, and that the noise model must be selected judiciously in order to estimate the frequency precision.

© 2005 Optical Society of America

OCIS Codes
(120.5050) Instrumentation, measurement, and metrology : Phase measurement
(170.3340) Medical optics and biotechnology : Laser Doppler velocimetry
(170.4500) Medical optics and biotechnology : Optical coherence tomography

ToC Category:
Research Papers

History
Original Manuscript: December 3, 2004
Revised Manuscript: December 29, 2004
Published: January 24, 2005

Citation
Siavash Yazdanfar, Changhuei Yang, Marinko Sarunic, and Joseph Izatt, "Frequency estimation precision in Doppler optical coherence tomography using the Cramer-Rao lower bound," Opt. Express 13, 410-416 (2005)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-13-2-410


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