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Optics Express

Optics Express

  • Editor: Michael Duncan
  • Vol. 13, Iss. 21 — Oct. 17, 2005
  • pp: 8339–8348

Study of photon migration with various source-detector separations in near-infrared spectroscopic brain imaging based on three-dimensional Monte Carlo modeling

Cheng-Kuang Lee, Chia-Wei Sun, Po-Lei Lee, Hsiang-Chieh Lee, C. C. Yang, Cho-Pei Jiang, Yuh-Ping Tong, Tzu-Chen Yeh, and Jen-Chuen Hsieh  »View Author Affiliations


Optics Express, Vol. 13, Issue 21, pp. 8339-8348 (2005)
http://dx.doi.org/10.1364/OPEX.13.008339


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Abstract

We have simulated the photon migration with various source-detector separations based on a three-dimensional Monte Carlo code. The whole brain MRI structure images are introduced in the simulation, and the brain model is more accurate then the previous studies. The brain model consists of scalp, skull, CSF layer, gray matter, and white matter. We demonstrate dynamic propagating movies under different source-detector separations. The multiple backscattered intensity from every layer of the brain model is obtained by marking the deepest layer which every photon can reach. Also the influences of an absorption target on brain cortex are revealed.

© 2005 Optical Society of America

OCIS Codes
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.5280) Medical optics and biotechnology : Photon migration

ToC Category:
Research Papers

History
Original Manuscript: August 1, 2005
Revised Manuscript: September 13, 2005
Published: October 17, 2005

Citation
Cheng-Kuang Lee, Chia-Wei Sun, Po-Lei Lee, Hsiang-Chieh Lee, C. Yang, Cho-Pei Jiang, Yuh-Ping Tong, Tzu-Chen Yeh, and Jen-Chuen Hsieh, "Study of photon migration with various source-detector separations in near-infrared spectroscopic brain imaging based on three-dimensional Monte Carlo modeling," Opt. Express 13, 8339-8348 (2005)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-13-21-8339


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