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Optics Express

Optics Express

  • Editor: Micha
  • Vol. 13, Iss. 23 — Nov. 14, 2005
  • pp: 9480–9491

Retinal nerve fiber layer thickness map determined from optical coherence tomography images

Mircea Mujat, Raymond C. Chan, Barry Cense, B. Hyle Park, Chulmin Joo, Taner Akkin, Teresa C. Chen, and Johannes F. de Boer  »View Author Affiliations


Optics Express, Vol. 13, Issue 23, pp. 9480-9491 (2005)
http://dx.doi.org/10.1364/OPEX.13.009480


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Abstract

We introduce a method to determine the retinal nerve fiber layer (RNFL) thickness in OCT images based on anisotropic noise suppression and deformable splines. Spectral-Domain Optical Coherence Tomography (SDOCT) data was acquired at 29 kHz A-line rate with a depth resolution of 2.6 μm and a depth range of 1.6 mm. Areas of 9.6×6.4 mm2 and 6.4×6.4 mm2 were acquired in approximately 6 seconds. The deformable spline algorithm determined the vitreous-RNFL and RNFL-ganglion cell/inner plexiform layer boundary, respectively, based on changes in the reflectivity, resulting in a quantitative estimation of the RNFL thickness. The thickness map was combined with an integrated reflectance map of the retina and a typical OCT movie to facilitate clinical interpretation of the OCT data. Large area maps of RNFL thickness will permit better longitudinal evaluation of RNFL thinning in glaucoma.

© 2005 Optical Society of America

OCIS Codes
(100.0100) Image processing : Image processing
(170.4470) Medical optics and biotechnology : Ophthalmology
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine

ToC Category:
Research Papers

History
Original Manuscript: August 22, 2005
Revised Manuscript: October 31, 2005
Published: November 14, 2005

Citation
Mircea Mujat, Raymond Chan, Barry Cense, B. Park, Chulmin Joo, Taner Akkin, Teresa Chen, and Johannes de Boer, "Retinal nerve fiber layer thickness map determined from optical coherence tomography images," Opt. Express 13, 9480-9491 (2005)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-13-23-9480


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