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Optics Express

Optics Express

  • Editor: Michael Duncan
  • Vol. 13, Iss. 25 — Dec. 12, 2005
  • pp: 10182–10199

Evaluation of anatomical structure and non-uniform distribution of imaging agent in near-infrared fluorescence-enhanced optical tomography

Amit K. Sahu, Ranadhir Roy, Amit Joshi, and Eva M. Sevick-Muraca  »View Author Affiliations


Optics Express, Vol. 13, Issue 25, pp. 10182-10199 (2005)
http://dx.doi.org/10.1364/OPEX.13.010182


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Abstract

To date, the assessment of fluorescence-enhanced optical imaging has not been performed owing to (i) the lack of tools necessary for objective assessment of image quality (OAIQ), and (ii) the difficulty to test an untested diagnostic contrast agent in patient studies. Herein, we focus upon the development of a framework for OAIQ which includes a model to simulate both natural tissue heterogeneity as well as heterogeneous distribution of a molecularly targeted fluorophore. Specifically, we use a novel tomographic algorithm previously developed and validated in our laboratory (Roy and Sevick-Muraca, IEEE Trans. Med. Imaging, 2005). Our results show that image generation is (i) unaffected by normal anatomical heterogeneity manifested in endogenous tissue optical properties of absorption and scattering, and (ii) restricted by heterogeneous distribution of fluorophore in the background as the contrast is decreased.

© 2005 Optical Society of America

OCIS Codes
(110.3000) Imaging systems : Image quality assessment
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.5280) Medical optics and biotechnology : Photon migration

ToC Category:
Research Papers

Virtual Issues
Vol. 1, Iss. 1 Virtual Journal for Biomedical Optics

Citation
Amit K. Sahu, Ranadhir Roy, Amit Joshi, and Eva M. Sevick-Muraca, "Evaluation of anatomical structure and non-uniform distribution of imaging agent in near-infrared fluorescence-enhanced optical tomography," Opt. Express 13, 10182-10199 (2005)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-13-25-10182


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