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Optics Express

Optics Express

  • Editor: Michael Duncan
  • Vol. 13, Iss. 3 — Feb. 7, 2005
  • pp: 985–997

Experimental investigation of perturbation Monte-Carlo based derivative estimation for imaging low-scattering tissue

Phaneendra K. Yalavarthy, Kirtish Karlekar, H. S. Patel, R. M. Vasu, Manojit Pramanik, P. C. Mathias, B. Jain, and P. K. Gupta  »View Author Affiliations

Optics Express, Vol. 13, Issue 3, pp. 985-997 (2005)

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Experimental results for imaging the low-scattering tissue phantoms based on the derivative estimation through perturbation Monte-Carlo (pMC) method are presented. It is proven that pMC-based methods give superior reconstructions compared to diffusion-based reconstruction methods. An easy way to estimate the Jacobian using analytical expression obtained from perturbation Monte-Carlo method is employed. Simulation studies on the same objects, considered in the experiment, are performed and corresponding results are found to be in reasonable agreement with the experimental studies. It is shown that inter-parameter cross talk in diffusion based methods lead to false results for the low-scattering tissue, where as the pMC-based method gives accurate results.

© 2005 Optical Society of America

OCIS Codes
(100.3190) Image processing : Inverse problems
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(170.5280) Medical optics and biotechnology : Photon migration
(170.6920) Medical optics and biotechnology : Time-resolved imaging
(170.7050) Medical optics and biotechnology : Turbid media

ToC Category:
Research Papers

Original Manuscript: November 30, 2004
Revised Manuscript: January 24, 2005
Published: February 7, 2005

Phaneendra Yalavarthy, Kirtish Karlekar, H. Patel, R. Vasu, Manojit Pramanik, P. Mathias, B. Jain, and P. Gupta, "Experimental investigation of perturbation Monte-Carlo based derivative estimation for imaging low-scattering tissue," Opt. Express 13, 985-997 (2005)

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