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Optics Express

Optics Express

  • Editor: Michael Duncan
  • Vol. 13, Iss. 9 — May. 2, 2005
  • pp: 3252–3258

In vivo retinal optical coherence tomography at 1040 nm-enhanced penetration into the choroid

A. Unterhuber, B. Považay, B. Hermann, H. Sattmann, A. Chavez-Pirson, and W. Drexler  »View Author Affiliations


Optics Express, Vol. 13, Issue 9, pp. 3252-3258 (2005)
http://dx.doi.org/10.1364/OPEX.13.003252


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Abstract

For the first time in vivo retinal imaging has been performed with a new compact, low noise Yb-based ASE source operating in the 1 µm range (NP Photonics, λc=1040 nm, Δλ=50 nm, Pout=30 mW) at the dispersion minimum of water with ~7 µm axial resolution. OCT tomograms acquired at 800 nm are compared to those achieved at 1040 nm showing about 200 µm deeper penetration into the choroid below the retinal pigment epithelium. Retinal OCT at longer wavelengths significantly improves the visualization of the retinal pigment epithelium/choriocapillaris/choroid interface and superficial choroidal layers as well as reduces the scattering through turbid media and therefore might provide a better diagnosis tool for early stages of retinal pathologies such as age related macular degeneration which is accompanied by choroidal neovascularization, i.e. extensive growth of new blood vessels in the choroid and retina.

© 2005 Optical Society of America

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4470) Medical optics and biotechnology : Ophthalmology
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(330.4460) Vision, color, and visual optics : Ophthalmic optics and devices

ToC Category:
Research Papers

History
Original Manuscript: March 8, 2005
Revised Manuscript: April 14, 2005
Published: May 2, 2005

Citation
Angelika Unterhuber, B. Považay, B. Hermann, H. Sattmann, A. Chavez-Pirson, and W. Drexler, "In vivo retinal optical coherence tomography at 1040 nm - enhanced penetration into the choroid," Opt. Express 13, 3252-3258 (2005)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-13-9-3252


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References

  1. D. Huang, E.A. Swanson, C.P. Lin, J.S. Schuman, W.G. Stinson, W. Chang, M.R. Hee, T. Flotte, K. Gregory, C.A. Puliafito, and J. G. Fujimoto, �??Optical coherence tomography,�?? Science 254, 1178-81 (1991). [CrossRef] [PubMed]
  2. J.S. Schuman, C.A. Puliafito, and J. G. Fujimoto, �??Optical coherence tomography of ocular disease,�?? Slack Inc, Thorofare, New Jersey (2004).
  3. J. G. Fujimoto, M. E Brezinski., G. J. Tearney, S. A. Boppart, B. Bouma, M. R. Hee, J. F. Southern, and E. A. Swanson,�??Optical biopsy and imaging using optical coherence tomography,�?? Nature Medicine 1, 970-2 (1995). [CrossRef] [PubMed]
  4. A. F. Fercher, �??Optical coherence tomography,�?? J. Biomed. Opt. 1, 157-73 (1996) [CrossRef]
  5. W. Drexler, U. Morgner, F. X. Kärtner, C. Pitris, S. A. Boppart, X. D. Li, E. P. Ippen, and J. G. Fujimoto, �??In vivo ultrahigh resolution optical coherence tomography,�?? Opt. Lett. 24, 1221-1223 (1999). [CrossRef]
  6. W. Drexler, U. Morgner, R. K. Ghanta, J. S. Schuman, F. X. Kärtner, and J. G. Fujimoto, �??Ultrahigh-resolution ophthalmic optical coherence tomography,�?? Nature Medicine 7, 502-507 (2001). [CrossRef] [PubMed]
  7. W. Drexler, H. Sattmann, B. Hermann, T. H. Ko, M. Stur, A. Unterhuber, C. Scholda, O. Findl, M. Wirtitsch, J. G. Fujimoto, and A. F. Fercher, �??Enhanced visualization of macular pathology with the use of ultrahigh-resolution optical coherence tomography,�?? Arch. Ophthalmol 121, 695-706 (2003). [CrossRef] [PubMed]
  8. W. Drexler, �??Ultrahigh resolution optical coherence tomography,�?? J. Biomed. Opt. 9 (1), 47-74 (2004). [CrossRef] [PubMed]
  9. B. Považay, K. Bizheva, A. Unterhuber, B. Hermann, H. Sattmann, A. F. Fercher, W. Drexler, A. Apolonski, W. J. Wadsworth, J. C. Knight, P. S. J. Russell, M. Vetterlein, and E. Scherzer, �??Submicrometer axial resolution optical coherence tomography,�?? Opt. Lett. 27, 1800-1803 (2002) [CrossRef]
  10. T. H. Ko, J. G. Fujimoto, J. S. Duker, L. A. Paunescu, W. Drexler, C. R. Baumal, C. A. Puliafito, E. Reichel, A. H. Rogers, and J. S. Schuman, �??Comparison of ultrahigh- and standard- resolution optical coherence tomography for imaging macular hole pathology and repair,�?? Ophthalmology 111, 2033-2043 (2004). [CrossRef] [PubMed]
  11. E. Ergun, B. Hermann, M. Wirtitsch, A. Unterhuber, T. H. Ko, H. Sattmann, C. Scholda, J. G. Fujimoto, M. Stur, and W. Drexler, �??Assessment of central visual function in Stargardt`s disease/Fundus flavimaculatus with ultrahigh-resolution optical coherence tomography,�?? Invest. Ophthalmo. Vis. Sci. 46, 310-316 (2005) [CrossRef]
  12. G. Wollstein, L. A. Paunescu, T. H. Ko, J. G. Fujimoto, A. Kowalevicz, I. Hartl, S. Beaton, H. Ishikawa, C. Mattox, O. Singh, J. Duker, W. Drexler , and J. S. Schuman, �??Ultrahigh-resolution optical coherence tomography in glaucoma,�?? Ophthalmology 112, 229-237 (2005). [CrossRef] [PubMed]
  13. M. Hammer, A. Roggan, D. Schweitzer and G. Müller, �??Optical properties of ocular fundus tissues-an in vitro study using the double-integrating-sphere technique and inverse Monte Carlo simulation,�?? Phys. Med. Biol. 40, 963-978 (1995). [CrossRef] [PubMed]
  14. American National Standards Institute, �??American National Standard for Safe Use of Lasers,�?? ANSI Z 136-1 (2000).
  15. International Comission of Non-Ionizing Radiation Protection, �??Revision of guidelines on limits of exposure to laser radiation of wavelengths between 400 nm and 1.4 µm,�?? Health Phy. 79, 432-440 (2000).
  16. G. M. Hale, and M. R. Querry, �??Optical constants of water in the 200 nm to 200 µm wavelength region," Appl. Opt. 12, 555-563 (1973). [CrossRef] [PubMed]
  17. B. Považay, K. Bizheva, B. Hermann, A. Unterhuber, H. Sattmann, A. F. Fercher, W. Drexler, C. Schubert, P. K. Ahnelt, M. Mei, R. Holzwarth, W. Wadsworth, J. Knight, and P. Russell, �??Enhanced visualization of choriodal vessels using ultrahigh resolution ophthalmic OCT at 1050 nm,�?? Opt. Express 11, 1980-1986 (2003) <a href="http://www.opticsexpress.org/abstract.cfm?URI=OPEX-11-17-1980">http://www.opticsexpress.org/abstract.cfm?URI=OPEX-11-17-1980</a>. [CrossRef] [PubMed]
  18. A. Unterhuber, B. Hermann, H. Sattmann, W. Drexler, V. Yakovlev, G. Tempea, C. Schubert, E. M. Anger, P. K. Ahnelt, M. Stur, J. E. Morgan, A. Cowey, G. Jung, T. Le, and A. Stingl, �??Compact, low-cost Ti:Al2O3 laser for in vivo ultrahigh-resolution optical coherence tomography,�?? Opt. Lett. 28, 905-907 (2003) [CrossRef] [PubMed]
  19. S. H. Yun, G. J. Tearney, B. E. Bouma, B. H. Park, and J. F. de Boer, �??High-speed spectral-domain optical coherence tomography at 1.3 µm wavelength,�?? Opt. Express 11, 3598-3604 (2003) <a href="http://www.opticsexpress.org/abstract.cfm?URI=OPEX-11-26-3598">http://www.opticsexpress.org/abstract.cfm?URI=OPEX-11-26-3598</a>. [CrossRef] [PubMed]

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