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Optics Express

Optics Express

  • Editor: Michael Duncan
  • Vol. 14, Iss. 13 — Jun. 26, 2006
  • pp: 5937–5944

Optical frequency domain imaging with a rapidly swept laser in the 815–870 nm range

H. Lim, J. F. de Boer, B. H. Park, E. C. W. Lee, R. Yelin, and S. H. Yun  »View Author Affiliations


Optics Express, Vol. 14, Issue 13, pp. 5937-5944 (2006)
http://dx.doi.org/10.1364/OE.14.005937


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Abstract

Optical frequency domain imaging (OFDI) in the 800-nm biological imaging window is demonstrated by using a novel wavelength-swept laser source. The laser output is tuned continuously from 815 to 870 nm at a 43.2-kHz repetition rate with 7-mW average power. Axial resolution of 10-µm in biological tissue and peak sensitivity of 96 dB are achieved. In vivo imaging of Xenopus laevis is demonstrated with an acquisition speed of 84 frames per second (512 axial lines per frame). This new imaging technique may prove useful in comprehensive retinal screening for medical diagnosis and contrast-agent-based imaging for biological investigations.

© 2006 Optical Society of America

OCIS Codes
(110.4500) Imaging systems : Optical coherence tomography
(120.3180) Instrumentation, measurement, and metrology : Interferometry
(140.3600) Lasers and laser optics : Lasers, tunable
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4470) Medical optics and biotechnology : Ophthalmology
(330.4460) Vision, color, and visual optics : Ophthalmic optics and devices

ToC Category:
Imaging Systems

History
Original Manuscript: April 18, 2006
Revised Manuscript: June 9, 2006
Manuscript Accepted: June 14, 2006
Published: June 26, 2006

Virtual Issues
Vol. 1, Iss. 7 Virtual Journal for Biomedical Optics

Citation
H. Lim, J. F. de Boer, B. H. Park, E. C. Lee, R. Yelin, and S. H. Yun, "Optical frequency domain imaging with a rapidly swept laser in the 815-870 nm range," Opt. Express 14, 5937-5944 (2006)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-14-13-5937


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References

  1. D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography," Science 254, 1178-1181 (1991). [CrossRef] [PubMed]
  2. W. Sorin, Optical reflectometry for component characterization, in Fiber Optic Test and Measurement D. Derickson, ed., (Prentice Hall PTR, 1998).
  3. A. F. Fercher, C. K. Hitzenberger, G. Kamp, and S. Y. Elzaiat, "Measurement of intraocular distances by backscattering spectral interferometry," Opt. Commun. 117, 43-48 (1995). [CrossRef]
  4. S. R. Chinn, E. A. Swanson, and J. G. Fujimoto, "Optical coherence tomography using a frequency-tunable optical source," Opt. Lett. 22, 340-342 (1997). [CrossRef] [PubMed]
  5. B. Golubovic, B. E. Bouma, G. J. Tearney, and J. G. Fujimoto, "Optical frequency-domain reflectometry using rapid wavelength tuning of a Cr/sup 4+/:forsterite laser," Opt. Lett. 22, 1704-1706 (1997). [CrossRef]
  6. S. H. Yun, G. J. Tearney, J. F. de Boer, N. Iftimia, and B. E. Bouma, "High-speed optical frequency-domain imaging," Opt. Express 11, 2953-2963 (2003). [CrossRef] [PubMed]
  7. M. A. Choma, M. V. Sarunic, C. H. Yang, and J. A. Izatt, "Sensitivity advantage of swept source and Fourier domain optical coherence tomography," Opt. Express 11, 2183-2189 (2003). [CrossRef] [PubMed]
  8. R. Huber, M. Wojtkowski, and J. G. Fujimoto, "Fourier Domain Mode Locking (FDML): A new laser operating regime and applications for optical coherence tomography," Opt. Express 14,3225-3237 (2006). [CrossRef] [PubMed]
  9. R. Huber, M. Wojtkowski, K. Taira, J. G. Fujimoto, and K. Hsu, "Amplified, frequency swept lasers for frequency domain reflectometry and OCT imaging: design and scaling principles," Opt. Express 13, 3513-3528 (2005). [CrossRef] [PubMed]
  10. B. J. Vakoc, S. H. Yun, J. F. de Boer, G. J. Tearney, and B. E. Bouma, "Phase-resolved optical frequency domain imaging," Opt. Express 13,5483-5493 (2005). [CrossRef] [PubMed]
  11. Y. Yasuno, V. D. Madjarova, S. Makita, M. Akiba, A. Morosawa, C. Chong, T. Sakai, K. P. Chan, M. Itoh, and T. Yatagai, "Three-dimensional and high-speed swept-source optical coherence tomography for in vivo investigation of human anterior eye segments," Opt. Express 13, 10652-10664 (2005). [CrossRef] [PubMed]
  12. J. Zhang, W. G. Jung, J. S. Nelson, and Z. P. Chen, "Full range polarization-sensitive Fourier domain optical coherence tomography," Opt. Express 12, 6033-6039 (2004). [CrossRef] [PubMed]
  13. M. V. Sarunic, S. Weinberg, and J. A. Izatt, "Full-field swept-source phase microscopy," Opt. Lett. 31, 1462-1646 (2006). [CrossRef] [PubMed]
  14. W. Y. Oh, S. H. Yun, B. J. Vakoc, G. J. Tearney, and B. E. Bouma, "Ultrahigh-speed optical frequency domain imaging and application to ablation monitoring," Appl. Phys. Lett.103902 (2006). [CrossRef]
  15. E. C. W. Lee, J. F. de Boer, M. Mujat, H. Lim, and S. H. Yun, "In vivo optical frequency domain imaging of human retina and choroid," Opt. Express 14, 4403-4411 (2006), [CrossRef] [PubMed]
  16. M. R. Hee, J. A. Izatt, E. A. Swanson, D. Huang, J. S. Schuman, C. P. Lin, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography of the human retina," Arch. Ophthalmol. 113, 325-32 (1995). [CrossRef] [PubMed]
  17. W. Drexler, "Ultrahigh-resolution optical coherence tomography," J. Biomed. Opt. 9, 47-74 (2004). [CrossRef] [PubMed]
  18. M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, A. F. Fercher, "In vivo human retinal imaging by fourier domain optical coherence tomography," J. Biomed. Opt. 7, 457-463 (2002). [CrossRef] [PubMed]
  19. N. Nassif, B. Cense, B. Park, M. Pierce, S. Yun, B. Bouma, G. Tearney, T. Chen, and J. de Boer, "In vivo high-resolution video-rate spectral-domain optical coherence tomography of the human retina and optic nerve," Opt. Express 12, 367-376 (2004). [CrossRef] [PubMed]
  20. S. A. Boppart, A. L. Oldenburg, C. Xu, and D. L. Mark, "Optical probes and techniques for molecular contrast enhancement in coherence imaging," J. Biomed. Opt. 10, 041208 (2005). [CrossRef]
  21. S. H. Yun, G. J. Tearney, J. F. de Boer, and B. E. Bouma, "Removing the depth-degeneracy in optical frequency domain imaging with frequency shifting," Opt. Express 12, 4822-4828 (2004), [CrossRef] [PubMed]
  22. S. H. Yun, G. J. Tearney, J. F. de Boer, and B. E. Bouma, "Motion artifacts in optical coherence tomography with frequency-domain ranging," Opt. Express 12,2977-2998 (2004). [CrossRef] [PubMed]
  23. S. H. Yun, C. Boudoux, G. J. Tearney, and B. E. Bouma, "High-speed wavelength-swept semiconductor laser with a polygon-scanner-based wavelength filter," Opt. Lett. 28, 1981-1983 (2003). [CrossRef] [PubMed]
  24. M. Fukuda, Reliability and Degradation of Semiconductor Lasers and LEDs, (Artech House Publishers, 1991).
  25. B. M. Green, K. K. Chu, E. M. Chumbes, J. A. Smart, J. R. Shealy, and L. F. Eastman, "The effect of surface passivation on the microwave characteristicsof undoped AlGaN/GaN HEMTs," IEEE Electron. Dev. Lett. 21, 268-270 (2000). [CrossRef]
  26. B. H. Park, M. C. Pierce, B. Cense, S. H. Yun, M. Mujat, G. J. Tearney, B. E. Bouma, and J. F. de Boer, "Real-time fiber-based multi-functional spectral-domain optical coherence tomography at 1.3 μm," Opt. Express 13, 3931-3944 (2005). [CrossRef] [PubMed]
  27. S. A. Boppart, G. J. Tearney, B. E. Bouma, J. F. Southern, M. E. Brezinski, and J. G. Fujimoto, "Noninvasive assessment of the developing Xenopus cardiovascular system using optical coherence tomography," Proc. Natl. Acad. Sci. U.S.A. 94, 4256-4261 (1997). [CrossRef] [PubMed]
  28. K. D. Rao, M. A. Choma, S. Yazdanfar, A. M. Rollins, and J. A. Izatt, "Molecular contrast in optical coherence tomography by use of a pump-probe technique," Opt. Lett. 28, 340-342 (2003). [CrossRef] [PubMed]
  29. C. H. Yang, L. E. L. McGuckin, J. D. Simon, M. A. Choma, B. E. Applegate, and J. A. Izatt, "Spectral triangulation molecular contrast optical coherence tomography with indocyanine green as the contrast agent," Opt. Lett. 29, 2016-2018 (2004). [CrossRef] [PubMed]
  30. H. Cang, T. Sun, Z. Y. Li, J. Y. Chen, B. J. Wiley, Y. N. Xia, and X. D. Li, "Gold nanocages as contrast agents for spectroscopic optical coherence tomography," Opt. Lett. 30, 3048-3050 (2005). [CrossRef] [PubMed]

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