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Optics Express

Optics Express

  • Editor: Michael Duncan
  • Vol. 14, Iss. 14 — Jul. 10, 2006
  • pp: 6485–6501

Determination of the optical properties of tissue-simulating phantoms from interstitial frequency domain measurements of relative fluence and phase difference

Heping Xu and Michael S. Patterson  »View Author Affiliations

Optics Express, Vol. 14, Issue 14, pp. 6485-6501 (2006)

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We estimated the absorption and reduced scattering coefficients of tissue-simulating phantoms from interstitial measurements of the phase difference and relative amplitude signals at two distances from a sinusoidally modulated isotropic source. It was found that absorption and reduced scattering coefficients can be recovered within 10% and slightly over 10% respectively, using either the data collected by two detectors 3mm apart or by two detectors 5mm apart with light collected by one detector attenuated by a neutral density filter. This accuracy was achieved over a wide range of optical properties, µa=0.008 to 0.17mm-1 and µ s ’=0.3 to 1.8mm-1. Additional factors affecting accuracy including source anisotropy, uncertainty in fiber placement, phase amplitude crosstalk, and the forward light propagation model (the combined isotropic similarity model and standard diffusion approximation versus the modified spherical harmonics method) were studied by Monte Carlo simulations (first two factors) and experiments (last two factors).

© 2006 Optical Society of America

OCIS Codes
(170.5180) Medical optics and biotechnology : Photodynamic therapy
(170.5270) Medical optics and biotechnology : Photon density waves
(170.7050) Medical optics and biotechnology : Turbid media

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: May 11, 2006
Revised Manuscript: June 15, 2006
Manuscript Accepted: June 27, 2006
Published: July 10, 2006

Virtual Issues
Vol. 1, Iss. 8 Virtual Journal for Biomedical Optics

Heping Xu and Michael S. Patterson, "Determination of the optical properties of tissue-simulating phantoms from interstitial frequency domain measurements of relative fluence and phase difference," Opt. Express 14, 6485-6501 (2006)

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