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Optics Express

Optics Express

  • Editor: Michael Duncan
  • Vol. 14, Iss. 15 — Jul. 24, 2006
  • pp: 6713–6723

In-vivo NIR autofluorescence imaging of rat mammary tumors

Laure S. Fournier, Vincenzo Lucidi, Kirill Berejnoi, Theodore Miller, Stavros G. Demos, and Robert C. Brasch  »View Author Affiliations

Optics Express, Vol. 14, Issue 15, pp. 6713-6723 (2006)

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We investigate in vivo detection of mammary tumors in a rat model using autofluorescence imaging in the red and far-red spectral regions. The objective was to explore this method for non-invasive detection of malignant tumors and correlation between autofluorescence properties of tumors and their pathologic status. Eighteen tumor-bearing rats, bearing eight benign and seventeen malignant tumors were imaged. Autofluorescence images were acquired using spectral windows centered at 700-nm, 750-nm and 800-nm under laser excitation at 632.8-nm and 670-nm. Intensity in the autofluorescence images of malignant tumors under 670-nm excitation was higher than that of the adjacent normal tissue. whereas intensity of benign tumors was lower compared to normal tissue.

© 2006 Optical Society of America

OCIS Codes
(000.1430) General : Biology and medicine
(110.3080) Imaging systems : Infrared imaging
(170.1610) Medical optics and biotechnology : Clinical applications
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: March 9, 2006
Revised Manuscript: June 21, 2006
Manuscript Accepted: June 22, 2006
Published: July 24, 2006

Virtual Issues
Vol. 1, Iss. 8 Virtual Journal for Biomedical Optics

Laure S. Fournier, Vincenzo Lucidi, Kirill Berejnoi, Theodore Miller, Stavros G. Demos, and Robert C. Brasch, "In-vivo NIR autofluorescence imaging of rat mammary tumors," Opt. Express 14, 6713-6723 (2006)

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