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Optics Express

Optics Express

  • Editor: Michael Duncan
  • Vol. 14, Iss. 16 — Aug. 7, 2006
  • pp: 7109–7124

A linear, featured-data scheme for image reconstruction in time-domain fluorescence molecular tomography

Feng Gao, Huijuan Zhao, Yukari Tanikawa, and Yukio Yamada  »View Author Affiliations


Optics Express, Vol. 14, Issue 16, pp. 7109-7124 (2006)
http://dx.doi.org/10.1364/OE.14.007109


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Abstract

Fluorescence diffuse optical tomography (DOT) has attracted many attentions from the community of biomedical imaging, since it provides effective enhancement in imaging contrast. This modality is now rapidly evolving as a potential means of monitoring molecular events in small living organisms with help of molecule-specific contrast agents, referred to as fluorescence molecular tomography (FMT). FMT could greatly promote pathogenesis research, drug development, and therapeutic intervention. Although FMT in steady-state and frequency-domain modes have been heavily investigated, the extension to time-domain scheme is imminent for its several unique advantages over the others. By extending the previously developed generalized pulse spectrum technique for time-domain DOT, we propose a linear, featured-data image reconstruction algorithm for time-domain FMT that can simultaneously reconstruct both fluorescent yield and lifetime images of multiple fluorephores, and validate the methodology with simulated data.

© 2006 Optical Society of America

OCIS Codes
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.6280) Medical optics and biotechnology : Spectroscopy, fluorescence and luminescence
(170.6920) Medical optics and biotechnology : Time-resolved imaging
(170.6960) Medical optics and biotechnology : Tomography

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: May 17, 2006
Revised Manuscript: July 24, 2006
Manuscript Accepted: July 24, 2006
Published: August 7, 2006

Virtual Issues
Vol. 1, Iss. 9 Virtual Journal for Biomedical Optics

Citation
Feng Gao, Huijuan Zhao, Yukari Tanikawa, and Yukio Yamada, "A linear, featured-data scheme for image reconstruction in time-domain fluorescence molecular tomography," Opt. Express 14, 7109-7124 (2006)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-14-16-7109


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