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Optics Express

Optics Express

  • Editor: Michael Duncan
  • Vol. 14, Iss. 17 — Aug. 21, 2006
  • pp: 7642–7660

Assessment of a fluorescence-enhanced optical imaging system using the Hotelling observer

Amit K. Sahu, Amit Joshi, Matthew A. Kupinski, and Eva M. Sevick-Muraca  »View Author Affiliations

Optics Express, Vol. 14, Issue 17, pp. 7642-7660 (2006)

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This study represents a first attempt to assess the detection capability of a fluorescence-enhanced optical imaging system as quantified by the Hotelling observer. The imaging system is simulated by the diffusion approximation of the time-dependent radiative transfer equation, which describes near infra-red (NIR) light propagation through a breast phantom of clinically relevant volume. Random structures in the background are introduced using a lumpy-object model as a representation of anatomical structure as well as non-uniform distribution of disease markers. The systematic errors and noise associated with the actual experimental conditions are incorporated into the simulated boundary measurements to acquire imaging data sets. A large number of imaging data sets is considered in order to perform Hotelling observer studies. We find that the signal-to-noise ratio (SNR) of Hotelling observer (i) decreases as the strength of lumpy perturbations in the background increases, (ii) decreases as the target depth increases, and (iii) increases as excitation light leakage decreases, and reaches a maximum for filter optical density values of 5 or higher.

© 2006 Optical Society of America

OCIS Codes
(100.0100) Image processing : Image processing
(110.3000) Imaging systems : Image quality assessment
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.5280) Medical optics and biotechnology : Photon migration

ToC Category:
Imaging Systems

Original Manuscript: June 9, 2006
Revised Manuscript: August 10, 2006
Manuscript Accepted: August 14, 2006
Published: August 21, 2006

Virtual Issues
Vol. 1, Iss. 9 Virtual Journal for Biomedical Optics

Amit K. Sahu, Amit Joshi, Matthew A. Kupinski, and Eva M. Sevick-Muraca, "Assessment of a fluorescence-enhanced optical imaging system using the Hotelling observer," Opt. Express 14, 7642-7660 (2006)

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