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Optics Express

Optics Express

  • Editor: Michael Duncan
  • Vol. 14, Iss. 17 — Aug. 21, 2006
  • pp: 7661–7669

Optics InfoBase > Optics Express > Volume 14 > Issue 17 > Page 7661

Full-field time-encoded frequency-domain optical coherence tomography

Boris Považay, Angelika Unterhuber, Boris Hermann, Harald Sattmann, Holger Arthaber, and Wolfgang Drexler  »View Author Affiliations


Optics Express, Vol. 14, Issue 17, pp. 7661-7669 (2006)
http://dx.doi.org/10.1364/OE.14.007661


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Abstract

Ultrahigh axial resolution surface profiling as well as volumetric optical imaging based on time encoded optical coherence tomography in the frequency domain without any mechanical scanning element is presented. A frequency tuned broad bandwidth titanium sapphire laser is interfaced to an optical microscope (Axioskop 2 MAT, Carl Zeiss Meditec) that is enhanced with an interferometric imaging head. The system is equipped with a 640 × 480 pixel CMOS camera, optimized for the 800 nm wavelength tuning range for transmission and reflection measurements of a microscopic sample. Sample volume information over 1.3 × 1 × 0.2 mm3 with ~3 μm axial and ~4 μm transverse resolution in tissue is acquired by a single wavelength scan over more than 100 nm optical bandwidth from <760 to >860 nm with 128–2048 equidistant optical frequency steps with an acquisition time of 1 to 50 ms per step. Topography and tomography with a signal to noise ratio of 83 dB is demonstrated on test surfaces and biological specimen respectively. This novel OCT technique promises to enable high speed, three dimensional imaging by employing high frame rate cameras and state of the art tunable lasers in a mechanically stable environment, due to lack of moving components while reducing the intensity on the sample.

© 2006 Optical Society of America

OCIS Codes
(070.2590) Fourier optics and signal processing : ABCD transforms
(140.3590) Lasers and laser optics : Lasers, titanium
(140.3600) Lasers and laser optics : Lasers, tunable
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(170.6960) Medical optics and biotechnology : Tomography
(180.6900) Microscopy : Three-dimensional microscopy

ToC Category:
Imaging Systems

History
Original Manuscript: March 27, 2006
Revised Manuscript: June 19, 2006
Manuscript Accepted: June 20, 2006
Published: August 21, 2006

Virtual Issues
Vol. 1, Iss. 9 Virtual Journal for Biomedical Optics

Citation
Boris Považay, Angelika Unterhuber, Boris Hermann, Harald Sattmann, Holger Arthaber, and Wolfgang Drexler, "Full-field time-encoded frequency-domain optical coherence tomography," Opt. Express 14, 7661-7669 (2006)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-14-17-7661


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References

  1. D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical Coherence Tomography," Science 254, 1178-1181 (1991). [CrossRef] [PubMed]
  2. E. A. Swanson, D. Huang, M. R. Hee, J. G. Fujimoto, C. P. Lin, and C. A. Puliafito, "High-speed optical coherence domain reflectometry," Opt. Lett. 17, 151-153 (1992). [CrossRef] [PubMed]
  3. W. Drexler, U. Morgner, F. X. Kartner, C. Pitris, S. A. Boppart, X. D. Li, E. P. Ippen, and J. G. Fujimoto, "In vivo ultrahigh-resolution optical coherence tomography," Opt. Lett. 24, 1221-1223 (1999). [CrossRef]
  4. W. Drexler, U. Morgner, R. K. Ghanta, F. X. Kartner, J. S. Schuman, and J. G. Fujimoto, "Ultrahigh-resolution ophthalmic optical coherence tomography," Nat. Med. 7, 502-507 (2001). [CrossRef] [PubMed]
  5. W. Drexler, "Ultrahigh-resolution optical coherence tomography," J. Biomed. Opt. 9, 47-74 (2004). [CrossRef] [PubMed]
  6. B. Považay, K. Bizheva, A. Unterhuber, B. Hermann, H. Sattmann, A. F. Fercher, W. Drexler, A. Apolonski, W. J. Wadsworth, J. C. Knight, P. S. J. Russell, M. Vetterlein, and E. Scherzer, "Submicrometer axial resolution optical coherence tomography," Opt. Lett. 27, 1800-1802 (2002). [CrossRef]
  7. A. M. Rollins, M. D. Kulkarni, S. Yazdanfar, R. Ung-arunyawee, and J. A. Izatt, "In vivo video rate optical coherence tomography," Opt. Express 3, 219-229 (1998). [CrossRef] [PubMed]
  8. C. Hauger, M. Worz, and T. Hellmuth, "Interferometer for optical coherence tomography," Appl. Opt. 42, 3896-3902 (2003). [CrossRef] [PubMed]
  9. A. Dubois, K. Grieve, G. Moneron, R. Lecaque, L. Vabre, and C. Boccara, "Ultrahigh-resolution full-field optical coherence tomography," Appl. Opt. 43, 2874-2883 (2004). [CrossRef] [PubMed]
  10. Y. Yasuno, Y. Sutoh, M. Nakama, S. Makita, M. Roh, T. Yatagai, and M. Mori, "Spectral interferometric optical coherence tomography with nonlinear beta-barium borate time gating," Opt. Lett. 27, 403-405 (2002). [CrossRef]
  11. "Spectroscopic techniques for far infra-red, submillimetre and millimetre waves," D. H. Martin, ed. (North-Holland Publishing Co, Amsterdam, Netherlands, 1967), p. 400.
  12. S. H. Yun, G. J. Tearney, J. F. de-Boer, N. Iftimia, and B. E. Bouma, "High-speed optical frequency-domain imaging," Opt. Express 11 (2003). [PubMed]
  13. A. F. Fercher, C. K. Hitzenberger, G. Kamp, and S. Y. El-Zaiat, "Measurement of intraocular distances by backscattering spectral interferometry," Opt. Commun. 117, 43-48 (1995). [CrossRef]
  14. B. Golubovic, B. E. Bouma, G. J. Tearney, and J. G. Fujimoto, "Optical frequency-domain reflectometry using rapid wavelength tuning of a Cr4+:forsterite laser," Opt. Lett. 22, 1704-1706 (1997). [CrossRef]
  15. F. Lexer, C. K. Hitzenberger, A. F. Fercher, and M. Kulhavy, "Wavelength-tuning interferometry of intraocular distances," Appl. Opt. 36, 6548-6562 (1997). [CrossRef]
  16. G. Hausler, and M. W. Linduer, ""Coherence radar" and "spectral radar"-new tools for dermatological diagnosis," J. Biomed. Opt. 3, 21-31 (1998). [CrossRef]
  17. R. Leitgeb, C. K. Hitzenberger, and A. F. Fercher, "Performance of fourier domain vs. time domain optical coherence tomography," Opt. Express 11, 889-894 (2003). [CrossRef] [PubMed]
  18. M. A. Choma, M. V. Sarunic, C. H. Yang, and J. A. Izatt, "Sensitivity advantage of swept source and Fourier domain optical coherence tomography," Opt. Express 11, 2183-2189 (2003). [CrossRef] [PubMed]
  19. J. F. de Boer, B. Cense, B. H. Park, M. C. Pierce, G. J. Tearney, and B. E. Bouma, "Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomography," Opt. Lett. 28, 2067-2069 (2003). [CrossRef] [PubMed]
  20. M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A. F. Fercher, "In vivo human retinal imaging by Fourier domain optical coherence tomography," J. Biomed. Opt. 7, 457-463 (2002). [CrossRef] [PubMed]
  21. W. Y. Oh, S. H. Yun, G. J. Tearney, and B. E. Bouma, "115 kHz tuning repetition rate ultrahigh-speed wavelength-swept semiconductor laser," Opt. Lett. 30, 3159-3161 (2005). [CrossRef] [PubMed]
  22. R. A. Leitgeb, W. Drexler, A. Unterhuber, B. Hermann, T. Bajraszewski, T. Le, A. Stingl, and A. F. Fercher, "Ultrahigh resolution Fourier domain optical coherence tomography," Opt. Express 12, 2156-2165 (2004). [CrossRef] [PubMed]
  23. M. Wojtkowski, V. J. Srinivasan, T. H. Ko, J. G. Fujimoto, A. Kowalczyk, and J. S. Duker, "Ultrahigh-resolution, high-speed, Fourier domain optical coherence tomography and methods for dispersion compensation," Opt. Express 12, 2404-2422 (2004). [CrossRef] [PubMed]
  24. B. Cense, and N. A. Nassif, "Ultrahigh-resolution high-speed retinal imaging using spectral-domain optical coherence tomography," Opt. Express 12, 2435-2447 (2004). [CrossRef] [PubMed]
  25. R. A. Leitgeb, L. Schmetterer, W. Drexler, A. F. Fercher, R. J. Zawadzki, and T. Bajraszewski, "Real-time assessment of retinal blood flow with ultrafast acquisition by color Doppler Fourier domain optical coherence tomography," Opt. Express 11, 3116-3121 (2003). [CrossRef] [PubMed]
  26. B. R. White, M. C. Pierce, N. Nassif, B. Cense, B. Hyle Park, G. J. Tearney, B. E. Bouma, T. C. Chen, and J. F. de Boer, "In vivo dynamic human retinal blood flow imaging using ultra-high-speed spectral domain optical coherence tomography," Opt. Express 11, 3490 (2003). [CrossRef] [PubMed]
  27. N. A. Nassif, B. Cense, B. H. Park, M. C. Pierce, S. H. Yun, B. E. Bouma, G. J. Tearney, T. C. Chen, and J. F. de Boer, "In vivo high-resolution video-rate spectral-domain optical coherence tomography of the human retina and optic nerve," Opt. Express 12, 367-376 (2004). [CrossRef] [PubMed]
  28. M. Wojtkowski, A. Kowalczyk, R. Leitgeb, and A. F. Fercher, "Full range complex spectral optical coherence tomography technique in eye imaging," Opt. Lett. 27, 1415-1417 (2002). [CrossRef]
  29. A. Dubois, G. Moneron, K. Grieve, and A. C. Boccara, "Three-dimensional cellular-level imaging using full-field optical coherence tomography," Phys. Med. Biol. 49, 1227-1234 (2004). [CrossRef] [PubMed]
  30. G. Moneron, A. C. Boccara, and A. Dubois, "Stroboscopic ultrahigh-resolution full-field optical coherence tomography," Opt. Lett. 30, 1351-1353 (2005). [CrossRef] [PubMed]
  31. B. Grajciar, M. Pircher, A. F. Fercher, and R. A. Leitgeb, "Parallel Fourier domain optical coherence tomography for in vivo measurement of the human eye," Opt. Express 13, 1131-1137 (2005). [CrossRef] [PubMed]
  32. T. Endo, Y. Yasuno, F. Truffer, G. Aoki, S. Makita, M. Itoh, and T. Yatagai, "Line-field Fourier-domain optical coherence tomography," Proceedings of the SPIE The International Society for Optical Engineering 5690, 168-173 (2005).
  33. L. F. Yu, and M. K. Kim, "Full-color three-dimensional microscopy by wide-field optical coherence tomography," Opt. Express 12, 6632-6641 (2004). [CrossRef] [PubMed]
  34. D. Yelin, B. E. Bouma, N. Iftimia, and G. J. Tearney, "Three-dimensional spectrally encoded imaging," Opt. Lett. 28, 2321-2323 (2003). [CrossRef] [PubMed]
  35. A. Unterhuber, B. Považay, K. Bizheva, B. Hermann, H. Sattmann, A. Stingl, T. Le, M. Seefeld, R. Menzel, M. Preusser, H. Budka, C. Schubert, H. Reitsamer, P. K. Ahnelt, J. E. Morgan, A. Cowey, and W. Drexler, "Advances in broad bandwidth light sources for ultrahigh resolution optical coherence tomography," Phys. Med. Biol. 49, 1235-1246 (2004). [CrossRef] [PubMed]
  36. M.-K. Kim, "Tomographic three-dimensional imaging of a biological specimen using wavelength-scanning digital interference holography," Opt. Express 7, 305 (2000). [CrossRef] [PubMed]

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