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Optics Express

Optics Express

  • Editor: Michael Duncan
  • Vol. 14, Iss. 17 — Aug. 21, 2006
  • pp: 7723–7729

Monolithic integration of microfluidic channels and semiconductor lasers

Simon J. Cran-McGreehin, Kishan Dholakia, and Thomas F. Krauss  »View Author Affiliations

Optics Express, Vol. 14, Issue 17, pp. 7723-7729 (2006)

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We present a fabrication method for the monolithic integration of microfluidic channels into semiconductor laser material. Lasers are designed to couple directly into the microfluidic channel, allowing submerged particles pass through the output beams of the lasers. The interaction between particles in the channel and the lasers, operated in either forward or reverse bias, allows for particle detection, and the optical forces can be used to trap and move particles. Both interrogation and manipulation are made more amenable for lab-on-a-chip applications through monolithic integration. The devices are very small, they require no external optical components, have perfect intrinsic alignment, and can be created with virtually any planar configuration of lasers in order to perform a variety of tasks. Their operation requires no optical expertise and only low electrical power, thus making them suitable for computer interfacing and automation. Insulating the pn junctions from the fluid is the key challenge, which is overcome by using photo-definable SU8-2000 polymer.

© 2006 Optical Society of America

OCIS Codes
(130.0250) Integrated optics : Optoelectronics
(130.3120) Integrated optics : Integrated optics devices
(140.7010) Lasers and laser optics : Laser trapping

ToC Category:
Integrated Optics

Original Manuscript: July 14, 2006
Manuscript Accepted: July 25, 2006
Published: August 21, 2006

Virtual Issues
Vol. 1, Iss. 9 Virtual Journal for Biomedical Optics

Simon J. Cran-McGreehin, Kishan Dholakia, and Thomas F. Krauss, "Monolithic integration of microfluidic channels and semiconductor lasers," Opt. Express 14, 7723-7729 (2006)

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  1. P. R. T. Jess, V. Garcés-Chávez, D. Smith, M. Mazilu, L. Paterson, A. Riches, C. S. Herrington, W. Sibbett, and K. Dholakia, "Dual beam fibre trap for Raman micro-spectroscopy of single cells," Opt. Exp.,  14, 5779-5791 (2006). [CrossRef]
  2. P. L. Gourley, "Biocavity laser for high-speed cell and tumour biology," J. Phys. D: Appl. Phys. 36, R228-239(2003) [CrossRef]
  3. L. Paterson, B. Agate, M. Comrie, R. Ferguson, T. Lake, J. Morris, A. Carruthers, C. T. Brown, W. Sibbett, P. Bryant, F. Gunn-Moore, A. Riches, and Kishan Dholakiaet, "Photoporation and cell transfection using a violet diode laser," Opt. Express.,  13, 595-600 (2005). [CrossRef]
  4. A. Ashkin, J. M. Dziedzic and T. Yamane, "Optical trapping and manipulation of single cells using infrared laser beams," Nature,  330, 769-771 (1987). [CrossRef] [PubMed]
  5. S. Cran-McGreehin, T. Krauss, and K. Dholakia, "Integrated monolithic optical manipulation," Lab-on-a-Chip, DOI: 10.1039/b605237a (2006).
  6. F. V. Ignatovich and L. Novotny, "Real-time and background-free detection of nanoscale particles," Phys. Rev. Lett. 96, 013901 (2006). [CrossRef] [PubMed]

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