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Optics Express

Optics Express

  • Editor: Michael Duncan
  • Vol. 14, Iss. 17 — Aug. 21, 2006
  • pp: 7801–7809

In vivo mouse studies with bioluminescence tomography

Ge Wang, Wenxiang Cong, Kumar Durairaj, Xin Qian, Haiou Shen, Patrick Sinn, Eric Hoffman, Geoffrey McLennan, and Michael Henry  »View Author Affiliations

Optics Express, Vol. 14, Issue 17, pp. 7801-7809 (2006)

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Bioluminescence tomography (BLT) is a new molecular imaging mode, which is being actively developed to reveal molecular and cellular signatures as labeled by bioluminescent probes in a living small animal. This technology can help diagnose diseases, evaluate therapies, and facilitate drug development with mouse models. In this paper, we describe in vivo mouse experiments with BLT, and propose the reconstruction procedure of bioluminescent sources from optical data measured on the body surface of the mouse using a modality fusion approach. The results show the feasibility of our methodology for localization and quantification of the bioluminescent activities in vivo.

© 2006 Optical Society of America

OCIS Codes
(110.6960) Imaging systems : Tomography
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.3660) Medical optics and biotechnology : Light propagation in tissues

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: April 26, 2006
Revised Manuscript: July 27, 2006
Manuscript Accepted: July 27, 2006
Published: August 21, 2006

Virtual Issues
Vol. 1, Iss. 9 Virtual Journal for Biomedical Optics

Ge Wang, Wenxiang Cong, Kumar Durairaj, Xin Qian, Haiou Shen, Patrick Sinn, Eric Hoffman, Geoffrey McLennan, and Michael Henry, "In vivo mouse studies with bioluminescence tomography," Opt. Express 14, 7801-7809 (2006)

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