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Optics Express

Optics Express

  • Editor: Michael Duncan
  • Vol. 14, Iss. 18 — Sep. 4, 2006
  • pp: 8211–8223

A multilevel adaptive finite element algorithm for bioluminescence tomography

Yujie Lv, Jie Tian, Wenxiang Cong, Ge Wang, Jie Luo, Wei Yang, and Hui Li  »View Author Affiliations

Optics Express, Vol. 14, Issue 18, pp. 8211-8223 (2006)

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As a new mode of molecular imaging, bioluminescence tomography (BLT) has become a hot topic over the past two years. In this paper, a multilevel adaptive finite element algorithm is developed for BLT reconstruction. In this algorithm, the mesh is adaptively refined according to a posteriori error estimation, which helps not only to improve localization and quantification of sources but also to enhance the robustness and efficiency of reconstruction. In the numerical simulation, bioluminescent signals on the body surface of a heterogeneous phantom are synthesized in a molecular optical simulation environment (MOSE) that we developed to model the photon transportation via Monte Carlo simulation. The performance of the algorithm is evaluated in numerical tests involving single and multiple sources in various arrangements. The results demonstrate the merits and potential of the multilevel adaptive approach for BLT.

© 2006 Optical Society of America

OCIS Codes
(110.6960) Imaging systems : Tomography
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.6280) Medical optics and biotechnology : Spectroscopy, fluorescence and luminescence

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: March 16, 2006
Revised Manuscript: August 17, 2006
Manuscript Accepted: August 18, 2006
Published: September 1, 2006

Virtual Issues
Vol. 1, Iss. 10 Virtual Journal for Biomedical Optics

Yujie Lv, Jie Tian, Wenxiang Cong, Ge Wang, Jie Luo, Wei Yang, and Hui Li, "A multilevel adaptive finite element algorithm for bioluminescence tomography," Opt. Express 14, 8211-8223 (2006)

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