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Optics Express

Optics Express

  • Editor: Michael Duncan
  • Vol. 14, Iss. 18 — Sep. 4, 2006
  • pp: 8224–8231

Photonic crystal fiber long-period gratings for biochemical sensing

Lars Rindorf, Jesper B. Jensen, Martin Dufva, Lars Hagsholm Pedersen, Poul Erik Høiby, and Ole Bang  »View Author Affiliations

Optics Express, Vol. 14, Issue 18, pp. 8224-8231 (2006)

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We present experimental results showing that long-period gratings in photonic crystal fibers can be used as sensitive biochemical sensors. A layer of biomolecules was immobilized on the sides of the holes of the photonic crystal fiber and by observing the shift in the resonant wavelength of a long-period grating it was possible to measure the thickness of the layer. The long-period gratings were inscribed in a large-mode area silica photonic crystal fiber with a CO2 laser. The thicknesses of a monolayer of poly-L-lysine and double-stranded DNA was measured using the device. We find that the grating has a sensitivity of approximately 1.4nm/1nm in terms of the shift in resonance wavelength in nm per nm thickness of biomolecule layer.

© 2006 Optical Society of America

OCIS Codes
(060.2370) Fiber optics and optical communications : Fiber optics sensors
(170.1420) Medical optics and biotechnology : Biology

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: June 16, 2006
Revised Manuscript: July 18, 2006
Manuscript Accepted: July 27, 2006
Published: September 1, 2006

Virtual Issues
Vol. 1, Iss. 10 Virtual Journal for Biomedical Optics

Lars Rindorf, Jesper B. Jensen, Martin Dufva, Lars Hagsholm Pedersen, Poul Erik Høiby, and Ole Bang, "Photonic crystal fiber long-period gratings for biochemical sensing," Opt. Express 14, 8224-8231 (2006)

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  1. K. L. Brogan and D. R. Walt, "Optical fiber-based sensors: application to chemical biology," Current Opinion in Chemical Biology 9, 494-500 (2005). [CrossRef] [PubMed]
  2. G. Gauglitz, "Direct optical sensors: principles and selected applications," Anal. Bioanal. Chem. 381, 141-155 (2005). [CrossRef] [PubMed]
  3. O. S. Wolfbeis, "Fiber-optic chemical sensors and biosensors," Anal. Chem. 76, 3269-3283 (2004). [CrossRef] [PubMed]
  4. B. Lee, "Review of the present status of optical fiber sensors," Opt. Fiber Technol. 9, 57-79 (2003). [CrossRef]
  5. S. W. James and R. P. Tatam, "Optical fibre long-period grating sensors: Characteristics and application," Meas. Sci. Technol. 14, R49-R61 (2003). [CrossRef]
  6. M. P. DeLisa, Z. Zhang, M. Shiloach, S. Pilevar, C. C. Davis, J. S. Sirkis, andW. E. Bentley, "Evanescent Wave Long-Period Fiber Bragg Grating as an Immobilized Antibody Biosensor," Anal. Chem. 72, 2895-2900 (2000). [CrossRef] [PubMed]
  7. R. Slavik, J. Homola, and J. Ctyroky, "Single-mode optical fiber surface plasmon resonance sensor," Sens. Actuators B 54, 74-79 (1999). [CrossRef]
  8. Y. Zhang, H. Shibru, K. L. Cooper, and A. B. Wang, "Miniature fiber-optic multicavity Fabry-Perot interferometric biosensor," Opt. Lett. 30, 1021-1023 (2005). [CrossRef] [PubMed]
  9. P. Russell, "Review: Photonic Crystal Fibers," Science 299, 358-362 (2003). [CrossRef] [PubMed]
  10. J. C. Knight, T. A. Birks, P. S. J. Russell, and D. M. Atkin, "All-silica single-mode optical fiber with photonic crystal cladding," Opt. Lett. 21, 1547-1549 (1996). [CrossRef] [PubMed]
  11. J. M. Fini, "Microstructure fibres for optical sensing in gases and liquids," Meas. Sci. Technol. 15, 1120-1128 (2004). [CrossRef]
  12. M. A. van Eijkelenborg, M. C. J. Large, A. Argyros, J. Zagari, S. Manos, N. Issa, I. Bassett, S. Fleming, R. C. McPhedran, C. M. de Sterke, and N. A. P. Nicorovici, "Microstructured polymer optical fibre," Opt. Express 9, 319 - 327 (2001). [CrossRef] [PubMed]
  13. F. M. Cox, A. Argyros, and M. C. J. Large, "Ultracompact biochemical sensor built with two-dimensional photonic crystal microcavity," Opt. Express 14, 4135 (2006). [CrossRef] [PubMed]
  14. J. B. Jensen, L. H. Pedersen, P. E. Hoiby, L. B. Nielsen, T. P. Hansen, J. R. Folkenberg, J. Riishede, D. Noordegraaf, K. Nielsen, A. Carlsen, and A. Bjarklev, "Photonic crystal fiber based evanescent-wave sensor for detection of biomolecules in aqueous solutions," Opt. Lett. 29, 1974-1976 (2004). [CrossRef] [PubMed]
  15. J. B. Jensen, P. E. Hoiby, G. Emiliyanov, O. Bang, L. H. Pedersen, and A. Bjarklev, "Selective detection of antibodies in microstructured polymer optical fibers," Opt. Express 13, 5883-5889 (2005). [CrossRef] [PubMed]
  16. E. Chow, A. Grot, L. Mirkarimi, M. Sigalas, and G. Girolami, "Ultracompact biochemical sensor built with two-dimensional photonic crystal microcavity," Opt. Lett. 29, 1093-1095 (2004). [CrossRef] [PubMed]
  17. T.W. Koo, S. Chan, and A. A. Berlin, "Single-molecule detection of biomolecules by surface-enhanced coherent anti-Stokes Raman scattering," Opt. Lett. 30, 1024-1026 (2005). [CrossRef] [PubMed]
  18. R. Karlsson, A. Michaelsson, and L. Mattsson, "Kinetic-Analysis of Monoclonal Antibody-Antigen Interactions with a New Biosensor Based Analytical System," J. Immunol. Methods 145, 229-240 (1991). [CrossRef] [PubMed]
  19. D. A. Markov, K. Swinney, and D. J. Bornhop, "Label-free molecular interaction determinations with nanoscale interferometry," J. Am. Chem. Soc. 126, 16,659-16,664 (2004). [CrossRef]
  20. Http://www.crystal-fibre.com.
  21. G. Kakarantzas, T. A. Birks, and P. S. J. Russell, Opt. Lett. 27, 1013 (2002). [CrossRef]
  22. Y. Zhu, P. Shum, J.-H. Chong, M. K. Rao, and C. Lu, "Deep-notch, ultracompact long-period grating in a largemode- area photonic crystal fiber," Opt. Lett. 28, 2467-2469 (2003). [CrossRef] [PubMed]
  23. P. D. Sawant, G. S. Watson, S. Myhra, and D. V. Nicolau, "Hierarchy of DNA immobilization and hybridization on poly-L-lysine using an atomic force microscopy study," J. Nanosci. Nanotechnol. 5, 951-957 (2005). [CrossRef] [PubMed]
  24. L. Rindorf, P. E. Hoiby, J. B. Jensen, L. H. Pedersen, O. Bang, and O. Geschke, "Biomolecule detection with integrated evanescent-wave microstructured optical fibre sensor," Anal. Bioanal. Chem.1-6 (Jan 2006) [PubMed]
  25. <a href="Http://www.nuncbrand.com">Http://www.nuncbrand.com</a>.

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