OSA's Digital Library

Optics Express

Optics Express

  • Editor: Michael Duncan
  • Vol. 14, Iss. 19 — Sep. 18, 2006
  • pp: 8675–8684

Spectrally-modulated full-field optical coherence microscopy for ultrahigh-resolution endoscopic imaging

W.Y. Oh, B.E. Bouma, N. Iftimia, R. Yelin, and G.J. Tearney  »View Author Affiliations


Optics Express, Vol. 14, Issue 19, pp. 8675-8684 (2006)
http://dx.doi.org/10.1364/OE.14.008675


View Full Text Article

Enhanced HTML    Acrobat PDF (1670 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

Full-field optical coherence microscopy (FFOCM) utilizes coherence gating to obtain high-resolution optical sections in thick tissues. FFOCM is an attractive technology for endoscopic microscopy at the cellular level since it does not require a high NA objective lens or beam scanning and is therefore particularly amenable to miniaturization. In this manuscript, we present a novel scheme for conducting FFOCM that utilizes spectrally modulated, spatially incoherent illumination and a static Linnik interferometer. This approach is advantageous for endoscopic microscopy since it allows FFOCM to be conducted through a single multimode fiber optic imaging bundle and does not require moving parts in the endoscope probe. Images acquired from biological samples in free space demonstrate that this new method provides the same detailed microscopic structure as that of conventional FFOCM. High-resolution images were also obtained through a multimode fiber bundle, further supporting the potential of this method for endoscopic microscopy.

© 2006 Optical Society of America

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(180.3170) Microscopy : Interference microscopy

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: April 26, 2006
Revised Manuscript: August 8, 2006
Manuscript Accepted: August 9, 2006
Published: September 18, 2006

Virtual Issues
Vol. 1, Iss. 10 Virtual Journal for Biomedical Optics

Citation
W.-Y. Oh, B. E. Bouma, N. Iftimia, R. Yelin, and G. J. Tearney, "Spectrally-modulated full-field optical coherence microscopy for ultrahigh-resolution endoscopic imaging," Opt. Express 14, 8675-8684 (2006)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-14-19-8675


Sort:  Author  |  Year  |  Journal  |  Reset  

References

  1. M. Rajadhyaksha, R. R. Anderson, and R. H. Webb, "Video-rate confocal scanning laser microscope for imaging human tissue in vivo," Appl. Opt. 38, 2105-2115 (1999). [CrossRef]
  2. C. J. Koester, J. D. Auran, H. D. Rosskothen, G. J. Florakis, and R. B. Tackaberry, "Clinical microscopy of the cornea utilizing optical sectioning and high-numerical-aperture objective," J. Opt. Soc. Am. A 10, 1670-1679 (1993). [CrossRef] [PubMed]
  3. G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, "In vivo endoscopic optical biopsy with optical coherence tomography," Science 276, 2037-2039 (1997). [CrossRef] [PubMed]
  4. B. E. Bouma and G. J. Tearney, Handbook of optical coherence tomography (Marcel Dekker, New York, 2002).
  5. E. Beaurepaire, A. C. Boccara, M. Lebec, L. Blanchot, and H. Saint-Jalmes, "Full-field optical coherence microscopy," Opt. Lett. 23, 244-246 (1998). [CrossRef]
  6. A. Dubois, L. Vabre, A. C. Boccara, and E. Beaurepaire, "High-resolution full-field optical coherence tomography with a Linnik microscope," Appl. Opt. 41, 805-812 (2002). [CrossRef] [PubMed]
  7. L. Vabre, A. Dubois, and A. C. Boccara, "Thermal-light full-field optical coherence tomography," Opt. Lett. 27, 530-532 (2002). [CrossRef]
  8. A. Dubois, K. Grieve, G. Moneron, R. Lecaque, L. Vabre, and C. Boccara, "Ultrahigh-resolution full-field optical coherence tomography," Appl. Opt. 43, 2874-2883 (2004). [CrossRef] [PubMed]
  9. A. Dubois, G. Moneron, K. Grieve, A. C. Boccara, "Three-dimensional cellular-level imaging using full-field optical coherence tomographt," Phys. Med. Biol. 49, 1227-1234 (2004). [CrossRef] [PubMed]
  10. W. Y. Oh, B. E. Bouma, N. Iftimia, S. H. Yun, R. Yelin, and G. J. Tearney, "Ultrahigh-resolution full-field optical coherence microscopy using InGaAs camera," Opt. Express 14, 726-735 (2006), http://www.opticsinfobase.org/abstract.cfm?URI=oe-14-2-726 [CrossRef] [PubMed]
  11. S. M. Bentzen, "Evaluation of the spatial resolution of a CT scanner by direct analysis of the edge response function," Med. Phy. 10, 579-581 (1983). [CrossRef]
  12. D. J. Hall, J. C. Hebden, and D. T. Delpy, "Evaluation of spatial resolution as a function of thickness for time-resolved optical imaging of highly scattering media," Med. Phys. 24, 361-368 (1997). [CrossRef] [PubMed]
  13. http://www.mathworks.com/access/helpdesk/help/toolbox/images/fspecial.html
  14. G. S. Kino and S. S. C. Chim, "Mirau correlation microscope," Appl. Opt. 29, 3775-3783 (1990). [CrossRef] [PubMed]
  15. A. F. Gmitro and D. Aziz, "Confocal microscopy through a fiber-optic imaging bundle," Opt. Lett. 18, 565-567 (1993). [CrossRef] [PubMed]
  16. P. M. Lane, A. L. P. Dlugan, R. Richards-Kortum, and C. E. MacAulay, "Fiber-optic confocal microscopy using a spatial light modulator," Opt. Lett. 25, 1780-1782 (2000). [CrossRef]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.

Supplementary Material


» Media 1: AVI (14876 KB)     
» Media 2: AVI (2454 KB)     
» Media 3: AVI (14493 KB)     
» Media 4: AVI (2465 KB)     
» Media 5: AVI (10549 KB)     
» Media 6: AVI (1827 KB)     
» Media 7: AVI (4073 KB)     
» Media 8: AVI (1830 KB)     

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited