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Optics Express

Optics Express

  • Editor: Michael Duncan
  • Vol. 14, Iss. 22 — Oct. 30, 2006
  • pp: 10181–10194

Diffusing-wave spectroscopy from head-like tissue phantoms: influence of a non-scattering layer

Franck Jaillon, Sergey E. Skipetrov, Jun Li, Gregor Dietsche, Georg Maret, and Thomas Gisler  »View Author Affiliations

Optics Express, Vol. 14, Issue 22, pp. 10181-10194 (2006)

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We investigate the influence of a non-scattering layer on the temporal field autocorrelation function of multiple scattered light g(1)( r ,τ) from a multilayer turbid medium such as the human head. Data from Monte Carlo simulations show very good agreement with the predictions of the correlation-diffusion equation with boundary conditions taking into account non-diffusive light transport within the non-scattering layer. Field autocorrelation functions measured at the surface of a multilayer phantom including a non-scattering layer agree well with theory and simulations when the source-receiver distance is significantly larger than the depth and the thickness of the non-scattering layer. Our results show that for source-receiver distances large enough to probe the dynamics in the human cortex, the cortical diffusion coefficient obtained by analyzing field autocorrelation functions neglecting the presence of the non-scattering cerebrospinal fluid layer is underestimated by about 40% in situations representative of the human head.

© 2006 Optical Society of America

OCIS Codes
(030.6140) Coherence and statistical optics : Speckle
(170.5280) Medical optics and biotechnology : Photon migration
(290.1350) Scattering : Backscattering
(290.1990) Scattering : Diffusion
(290.4210) Scattering : Multiple scattering
(290.7050) Scattering : Turbid media

ToC Category:
Coherence and Statistical Optics

Original Manuscript: June 27, 2006
Revised Manuscript: August 18, 2006
Manuscript Accepted: September 26, 2006
Published: October 30, 2006

Virtual Issues
Vol. 1, Iss. 11 Virtual Journal for Biomedical Optics

Franck Jaillon, Sergey E. Skipetrov, Jun Li, Gregor Dietsche, Georg Maret, and Thomas Gisler, "Diffusing-wave spectroscopy from head-like tissue phantoms: influence of a non-scattering layer," Opt. Express 14, 10181-10194 (2006)

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