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Optics Express

Optics Express

  • Editor: Michael Duncan
  • Vol. 14, Iss. 25 — Dec. 11, 2006
  • pp: 12230–12242

Optics InfoBase > Optics Express > Volume 14 > Issue 25 > Page 12230

Multi-wavelength imaging with the adaptive optics scanning laser Ophthalmoscope

Kate Grieve, Pavan Tiruveedhula, Yuhua Zhang, and Austin Roorda  »View Author Affiliations


Optics Express, Vol. 14, Issue 25, pp. 12230-12242 (2006)
http://dx.doi.org/10.1364/OE.14.012230


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Abstract

The adaptive optics scanning laser ophthalmoscope has been fitted with three light sources of different wavelengths to allow simultaneous or separate imaging with one, two or three wavelength combinations. The source wavelengths used are 532 nm, 658 nm and 840 nm. Typically the instrument is used in dual-frame mode, performing imaging at 840 nm and precisely coincident retinal stimulation in one of the visible wavelengths. Instrument set-up and single-detector image capture are described. Simultaneous multi-wavelength imaging in the living human retina is demonstrated. The chromatic aberrations of the human eye lead to lateral and axial shifts, as well as magnification differences in the image, from one wavelength to another. Measurement of these chromatic effects is described for instrument characterization purposes.

© 2006 Optical Society of America

OCIS Codes
(010.1080) Atmospheric and oceanic optics : Active or adaptive optics
(170.0110) Medical optics and biotechnology : Imaging systems
(170.4470) Medical optics and biotechnology : Ophthalmology

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: September 7, 2006
Revised Manuscript: November 27, 2006
Manuscript Accepted: November 29, 2006
Published: December 11, 2006

Virtual Issues
Vol. 2, Iss. 1 Virtual Journal for Biomedical Optics

Citation
Kate Grieve, Pavan Tiruveedhula, Yuhua Zhang, and Austin Roorda, "Multi-wavelength imaging with the adaptive optics scanning laser Ophthalmoscope," Opt. Express 14, 12230-12242 (2006)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-14-25-12230


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References

  1. A. Roorda, F. Romero-Borja, W. Donnelly, III, H. Queener, T. Hebert, and M. Campbell, "Adaptive optics scanning laser ophthalmoscopy," Opt. Express 10,405-412 (2002). [PubMed]
  2. J. A. Martin. and A. Roorda, "Direct and non-invasive assessment of Parafoveal Capillary Leukocyte Velocity," Ophthalmology 112, 2219-2224 (2005). [CrossRef] [PubMed]
  3. S. Poonja, S. Patel, L. Henry, and A. Roorda, "Dynamic visual stimulus presentation in an adaptive optics scanning laser ophthalmoscope," Journal of Refractive Surgery 21,575-580 (2005).
  4. F. Reinholz, R. A. Ashman, and R. H. Eikelboom, "Simultaneous three wavelength imaging with a scanning Laser Ophthalmoscope," Cytometry 37,165-170 (1999). [CrossRef] [PubMed]
  5. Y. Zhang, S. Poonja, and A. Roorda, "MEMS-based adaptive optics scanning Laser Ophthalmoscopy," Opt. Lett. 31, 1268-1270 (2006). [CrossRef] [PubMed]
  6. D. C. Gray, W. Merigan, J. I. Wolfing, B. P. Gee, J. Porter, A. Dubra, T. H. Twietmeyer, K. Ahamd, R. Tumbar, F. Reinholz, and D. R. Williams, "In vivo fluorescence imaging of primate retinal ganglion cells and retinal pigment epithelial cells," Opt. Express 14, 7144-7158 (2006). [CrossRef] [PubMed]
  7. P. A. Howarth, and A. Bradley, "The Longitudinal chromatic aberration of the human eye, and its correction," Vision Res. 26, 361-366 (1986). [CrossRef] [PubMed]
  8. L. N. Thibos, A. Bradley, D. L. Still, X. Zhang, and P. A. Howarth, "Theory and measurement of Ocular Chromatic Aberration," Vision Res. 30,33-49 (1990). [CrossRef] [PubMed]
  9. P. Simonet, and M. C. W. Campbell, "The optical transverse chromatic aberration on the Fovea of the human eye," Vision Res. 30,187-206 (1990). [CrossRef] [PubMed]
  10. C. Wildsoet, D. A. Atchison, and M. J. Collins, "Longitudinal chromatic aberration as a function of refractive error," Clin. Exper. Optom. 76,119-122 (1993). [CrossRef]
  11. E. Fernandez, A. Unterhuber, B. Povazay, B. Hermann, P. Artal, and W. Drexler, "Chromatic aberration correction of the human eye for retinal imaging in the near infrared," Opt. Express 14, 6213-6225 (2006). [CrossRef] [PubMed]
  12. X. Zhang, L. N. Thibos, and A. Bradley, "Relation between the chromatic difference of refraction and the chromatic difference of magnification for the reduced eye," Optom Vision Sci. 68, 456-458 (1991). [CrossRef]
  13. X. Zhang, A. Bradley, and L. N. Thibos, "Experimental determination of the chromatic difference of magnification of the human eye and the location of the anterior nodal point," J. Opt. Soc. Am. A 10, 213-220 (1993). [CrossRef] [PubMed]
  14. Safe Use of Lasers, ANSI Z136.1-1993. New York: American National Standards Institute (1993) and ANSI, American National Standard for the Safe Use of Lasers, ANSI Z136.1 (Laser Institute of America, Orlando, FL, 2000).
  15. Y. Zhang and A. Roorda, "Evaluating the lateral resolution of the adaptive optics scanning Laser Ophthalmoscope," J. Biomed. Opt. 11, 014002 (2006). [CrossRef] [PubMed]
  16. K. Venkateswaran, F. Romero-Borja, and A. Roorda, "Theoretical modeling and evaluation of the axial resolution of the Adaptive Optics Scanning Laser Ophthalmoscope," J. Biomed. Opt. 9, 132-138 (2004). [CrossRef] [PubMed]
  17. S. Marcos, S. A. Burns, E. Moreno-Barriusop, and R. Navarro, "A new approach to the study of ocular chromatic aberrations," Vision Res. 39,4309-4323 (1999). [CrossRef]
  18. S. B. Stevenson and A. Roorda, "Correcting for miniature eye movements in high resolution scanning Laser Ophthalmoscopy" in Ophthalmic Technologies XV, F. Manns, P. Soderberg, and A. Ho, eds., Proc. SPIE Vol. 5688A, 145-151 (2005). [CrossRef]
  19. C. R. Vogel, D. W. Arathorn, A. Roorda, and A. Parker, "Retinal motion estimation in Adaptive Optics Scanning Laser Ophthalmoscopy," Opt. Express 14,487-497 (2006). [CrossRef] [PubMed]
  20. H. Hofer, L. Chen, G. -Y. Yoon, B. Singer, Y. Yamauchi and D. R. Williams, "Improvement in retinal image quality with dynamic correction of the eye's aberrations," Opt. Express 8, 631-643 (2001). [CrossRef] [PubMed]
  21. A. Roorda and D. R. Williams, "The arrangement of the three cone classes in the living human eye," Nature 397, 520-522 (1999). [CrossRef] [PubMed]
  22. J. I. YellotJr, "Spectral analysis of spatial sampling by photoreceptors: Topological disorder prevents aliasing," Vision Res. 22, 1205-1210 (1982). [CrossRef]

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