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Optics Express

Optics Express

  • Editor: Michael Duncan
  • Vol. 14, Iss. 25 — Dec. 11, 2006
  • pp: 12255–12270

Time resolved fluorescence tomography of turbid media based on lifetime contrast

Anand T. N. Kumar, Scott B. Raymond, Gregory Boverman, David A. Boas, and Brian J. Bacskai  »View Author Affiliations


Optics Express, Vol. 14, Issue 25, pp. 12255-12270 (2006)
http://dx.doi.org/10.1364/OE.14.012255


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Abstract

A general linear model for time domain (TD) fluorescence tomography is presented that allows a lifetime-based analysis of the entire temporal fluorescence response from a turbid medium. Simulations are used to show that TD fluorescence tomography is optimally performed using two complementary approaches: A direct TD analysis of a few time points near the peak of the temporal response, which provides superior resolution; and an asymptotic multi-exponential analysis based tomography of the decay portion of the temporal response, which provides accurate localization of yield distributions for various lifetime components present in the imaging medium. These results indicate the potential of TD technology for biomedical imaging with lifetime sensitive targeted probes, and provide useful guidelines for an optimal approach to fluorescence tomography with TD data.

© 2006 Optical Society of America

OCIS Codes
(170.3650) Medical optics and biotechnology : Lifetime-based sensing
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.6920) Medical optics and biotechnology : Time-resolved imaging
(170.7050) Medical optics and biotechnology : Turbid media

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: October 6, 2006
Revised Manuscript: November 27, 2006
Manuscript Accepted: November 29, 2006
Published: December 11, 2006

Virtual Issues
Vol. 2, Iss. 1 Virtual Journal for Biomedical Optics

Citation
Anand T. Kumar, Scott B. Raymond, Gregory Boverman, David A. Boas, and Brian J. Bacskai, "Time resolved fluorescence tomography of turbid media based on lifetime contrast," Opt. Express 14, 12255-12270 (2006)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-14-25-12255


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