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Optics Express

Optics Express

  • Editor: Michael Duncan
  • Vol. 14, Iss. 25 — Dec. 11, 2006
  • pp: 12271–12287

Time-resolved absorption and hemoglobin concentration difference maps: a method to retrieve depth-related information on cerebral hemodynamics.

Bruno Montcel, Renée Chabrier, and Patrick Poulet  »View Author Affiliations

Optics Express, Vol. 14, Issue 25, pp. 12271-12287 (2006)

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Time-resolved diffuse optical methods have been applied to detect hemodynamic changes induced by cerebral activity. We describe a near infrared spectroscopic (NIRS) reconstruction free method which allows retrieving depth-related information on absorption variations. Variations in the absorption coefficient of tissues have been computed over the duration of the whole experiment, but also over each temporal step of the time-resolved optical signal, using the microscopic Beer-Lambert law. Finite element simulations show that time-resolved computation of the absorption difference as a function of the propagation time of detected photons is sensitive to the depth profile of optical absorption variations. Differences in deoxyhemoglobin and oxyhemoglobin concentrations can also be calculated from multi-wavelength measurements. Experimental validations of the simulated results have been obtained for resin phantoms. They confirm that time-resolved computation of the absorption differences exhibited completely different behaviours, depending on whether these variations occurred deeply or superficially. The hemodynamic response to a short finger tapping stimulus was measured over the motor cortex and compared to experiments involving Valsalva manoeuvres. Functional maps were also calculated for the hemodynamic response induced by finger tapping movements.

© 2006 Optical Society of America

OCIS Codes
(170.1470) Medical optics and biotechnology : Blood or tissue constituent monitoring
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(170.6920) Medical optics and biotechnology : Time-resolved imaging

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: July 18, 2006
Revised Manuscript: September 15, 2006
Manuscript Accepted: October 9, 2006
Published: December 11, 2006

Virtual Issues
Vol. 2, Iss. 1 Virtual Journal for Biomedical Optics

Bruno Montcel, Renée Chabrier, and Patrick Poulet, "Time-resolved absorption and hemoglobin concentration difference maps: a method to retrieve depth-related information on cerebral hemodynamics.," Opt. Express 14, 12271-12287 (2006)

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