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Optics Express

Optics Express

  • Editor: Michael Duncan
  • Vol. 14, Iss. 26 — Dec. 25, 2006
  • pp: 12930–12943

Increased optical contrast in imaging of epidermal growth factor receptor using magnetically actuated hybrid gold/iron oxide nanoparticles

Jesse S. Aaron, Junghwan Oh, Timothy A. Larson, Sonia Kumar, Thomas E. Milner, and Konstantin V. Sokolov  »View Author Affiliations


Optics Express, Vol. 14, Issue 26, pp. 12930-12943 (2006)
http://dx.doi.org/10.1364/OE.14.012930


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Abstract

We describe a new approach for optical imaging that combines the advantages of molecularly targeted plasmonic nanoparticles and magnetic actuation. This combination is achieved through hybrid nanoparticles with an iron oxide core surrounded by a gold layer. The nanoparticles are targeted in-vitro to epidermal growth factor receptor, a common cancer biomarker. The gold portion resonantly scatters visible light giving a strong optical signal and the superparamagnetic core provides a means to externally modulate the optical signal. The combination of bright plasmon resonance scattering and magnetic actuation produces a dramatic increase in contrast in optical imaging of cells labeled with hybrid gold/iron oxide nanoparticles.

© 2006 Optical Society of America

OCIS Codes
(170.1530) Medical optics and biotechnology : Cell analysis
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4090) Medical optics and biotechnology : Modulation techniques
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: October 18, 2006
Revised Manuscript: December 2, 2006
Manuscript Accepted: December 7, 2006
Published: December 22, 2006

Virtual Issues
Vol. 2, Iss. 1 Virtual Journal for Biomedical Optics

Citation
Jesse S. Aaron, Junghwan Oh, Timothy A. Larson, Sonia Kumar, Thomas E. Milner, and Konstantin V. Sokolov, "Increased optical contrast in imaging of epidermal growth factor receptor using magnetically actuated hybrid gold/iron oxide nanoparticles," Opt. Express 14, 12930-12943 (2006)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-14-26-12930


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