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Optics Express

Optics Express

  • Editor: Michael Duncan
  • Vol. 14, Iss. 3 — Feb. 6, 2006
  • pp: 1027–1032

Nonlinear optical endoscopy based on a double-clad photonic crystal fiber and a MEMS mirror

Ling Fu, Ankur Jain, Huikai Xie, Charles Cranfield, and Min Gu  »View Author Affiliations


Optics Express, Vol. 14, Issue 3, pp. 1027-1032 (2006)
http://dx.doi.org/10.1364/OE.14.001027


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Abstract

Two-photon fluorescence and second harmonic generation microscopy have enabled functional and morphological in vivo imaging. However, in vivo applications of those techniques to living animals are limited by bulk optics on a bench top. Fortunately, growing functionality of fiber-optic devices and miniaturization of scanning mirrors stimulate the race to develop nonlinear optical endoscopy. In this paper, we report on a prototype of a nonlinear optical endoscope based on a double-clad photonic crystal fiber to improve the detection efficiency and a MEMS mirror to steer the light at the fiber tip. The miniaturized fiber-optic nonlinear microscope is characterized by rat esophagus imaging. Line profiles from the rat tail tendon and esophagus prove the potential of the technology in in vivo applications.

© 2006 Optical Society of America

OCIS Codes
(110.0180) Imaging systems : Microscopy
(110.2350) Imaging systems : Fiber optics imaging
(180.2520) Microscopy : Fluorescence microscopy

ToC Category:
Imaging Systems

History
Original Manuscript: December 5, 2005
Revised Manuscript: January 20, 2006
Manuscript Accepted: January 22, 2006
Published: February 6, 2006

Virtual Issues
Vol. 1, Iss. 3 Virtual Journal for Biomedical Optics

Citation
Ling Fu, Ankur Jain, Huikai Xie, Charles Cranfield, and Min Gu, "Nonlinear optical endoscopy based on a double-clad photonic crystal fiber and a MEMS mirror," Opt. Express 14, 1027-1032 (2006)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-14-3-1027


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