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Optics Express

Optics Express

  • Editor: Michael Duncan
  • Vol. 14, Iss. 8 — Apr. 17, 2006
  • pp: 3368–3376

Registration of high-density cross sectional images to the fundus image in spectral-domain ophthalmic optical coherence tomography

Shuliang Jiao, Chunyan Wu, Robert W. Knighton, Giovanni Gregori, and Carmen A. Puliafito  »View Author Affiliations

Optics Express, Vol. 14, Issue 8, pp. 3368-3376 (2006)

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We previously developed a technique to acquire a SLO (scanning laser ophthalmoscope) like fundus intensity image from the raw spectra measured with spectral-domain optical coherence tomography (OCT), the same spectra used to generate a 3D OCT data set. This technique offers simultaneous fundus and OCT images and, therefore, solves the problem of registering a cross sectional OCT image to fundus features. However, the registration of high density OCT images is still an unsolved problem because no useful fundus image can be generated from the high density scans. High density OCT images can significantly improve the image quality and enhance the visualization of retinal structure, especially the structure of small lesions. We have developed a feature-based algorithm, which can register a high density OCT image on the fundus image generated from normal density scans. The algorithm was successfully tested for both normal and diseased eyes.

© 2006 Optical Society of America

OCIS Codes
(120.3890) Instrumentation, measurement, and metrology : Medical optics instrumentation
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: January 3, 2006
Revised Manuscript: March 27, 2006
Manuscript Accepted: April 3, 2006
Published: April 17, 2006

Virtual Issues
Vol. 1, Iss. 5 Virtual Journal for Biomedical Optics

Shuliang Jiao, Chunyan Wu, Robert W. Knighton, Giovanni Gregori, and Carmen A. Puliafito, "Registration of high-density cross sectional images to the fundus image in spectral-domain ophthalmic optical coherence tomography," Opt. Express 14, 3368-3376 (2006)

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