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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 15, Iss. 10 — May. 14, 2007
  • pp: 6121–6139

In vivo high-contrast imaging of deep posterior eye by 1-μm swept source optical coherence tomography and scattering optical coherence angiography

Yoshiaki Yasuno, Youngjoo Hong, Shuichi Makita, Masahiro Yamanari, Masahiro Akiba, Masahiro Miura, and Toyohiko Yatagai  »View Author Affiliations


Optics Express, Vol. 15, Issue 10, pp. 6121-6139 (2007)
http://dx.doi.org/10.1364/OE.15.006121


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Abstract

Retinal, choroidal and scleral imaging by using swept-source optical coherence tomography (SS-OCT) with a 1-μm band probe light, and high-contrast and three-dimensional (3D) imaging of the choroidal vasculature are presented. This SS-OCT has a measurement speed of 28,000 A-lines/s, a depth resolution of 10.4 μm in tissue, and a sensitivity of 99.3 dB. Owing to the high penetration of the 1-μm probe light and the high sensitivity of the system, the in vivo sclera of a healthy volunteer can be observed. A software-based algorithm of scattering optical coherence angiography (S-OCA) is developed for the high-contrast and 3D imaging of the choroidal vessels. The S-OCA is used to visualize the 3D choroidal vasculature of the in vivo human macula and the optic nerve head. Comparisons of S-OCA with several other angiography techniques including Doppler OCA, Doppler OCT, fluorescein angiography, and indocyanine green angiography are also presented.

© 2007 Optical Society of America

OCIS Codes
(100.2650) Image processing : Fringe analysis
(100.5010) Image processing : Pattern recognition
(100.6890) Image processing : Three-dimensional image processing
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.4470) Medical optics and biotechnology : Ophthalmology
(170.4500) Medical optics and biotechnology : Optical coherence tomography

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: January 2, 2007
Revised Manuscript: March 28, 2007
Manuscript Accepted: April 5, 2007
Published: May 3, 2007

Virtual Issues
Vol. 2, Iss. 6 Virtual Journal for Biomedical Optics

Citation
Yoshiaki Yasuno, Youngjoo Hong, Shuichi Makita, Masahiro Yamanari, Masahiro Akiba, Masahiro Miura, and Toyohiko Yatagai, "In vivo high-contrast imaging of deep posterior eye by 1-um swept source optical coherence tomography and scattering optical coherence angiography," Opt. Express 15, 6121-6139 (2007)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-15-10-6121


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