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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 15, Iss. 11 — May. 28, 2007
  • pp: 6583–6588

Molecular specific optoacoustic imaging with plasmonic nanoparticles

Srivalleesha Mallidi, Timothy Larson, Jesse Aaron, Konstantin Sokolov, and Stanislav Emelianov  »View Author Affiliations


Optics Express, Vol. 15, Issue 11, pp. 6583-6588 (2007)
http://dx.doi.org/10.1364/OE.15.006583


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Abstract

Gold nanoparticles functionalized with antibodies can specifically bind to molecular biomarkers such as epithelial growth factor receptor (EGFR). The molecule specific nature of the antibody-functionalized gold nanoparticles forms the basis for the developed optoacoustic imaging technique to detect cancer at an asymptotic stage. Optoacoustic imaging was performed with 532 nm and 680 nm pulsed laser irradiation on three-dimensional tissue phantoms prepared using a human keratinocyte cell line. The results of our study demonstrate that the combination of anti-EGFR gold bioconjugates and optoacoustic imaging can allow highly sensitive and selective detection of human epithelial cancer cells.

© 2007 Optical Society of America

OCIS Codes
(110.5120) Imaging systems : Photoacoustic imaging
(170.1530) Medical optics and biotechnology : Cell analysis
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(170.6930) Medical optics and biotechnology : Tissue

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: April 23, 2007
Revised Manuscript: May 11, 2007
Manuscript Accepted: May 11, 2007
Published: May 14, 2007

Virtual Issues
Vol. 2, Iss. 6 Virtual Journal for Biomedical Optics

Citation
Srivalleesha Mallidi, Timothy Larson, Jesse Aaron, Konstantin Sokolov, and Stanislav Emelianov, "Molecular specific optoacoustic imaging with plasmonic nanoparticles," Opt. Express 15, 6583-6588 (2007)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-15-11-6583


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