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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 15, Iss. 11 — May. 28, 2007
  • pp: 6643–6650

Activity of the human visual cortex measured non-invasively by diffusing-wave spectroscopy

Franck Jaillon, Jun Li, Gregor Dietsche, Thomas Elbert, and Thomas Gisler  »View Author Affiliations


Optics Express, Vol. 15, Issue 11, pp. 6643-6650 (2007)
http://dx.doi.org/10.1364/OE.15.006643


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Abstract

Activity of the human visual cortex, elicited by steady-state flickering at 8 Hz, is non-invasively probed by multi-speckle diffusing-wave spectroscopy (DWS). Parallel detection of the intensity fluctuations of statistically equivalent, but independent speckles allows to resolve stimulation-induced changes in the field autocorrelation of multiply scattered light of less than 2%. In a group of 9 healthy subjects we find a faster decay of the field autocorrelation function during the stimulation periods for data measured with a long-distance probe (30 mm source-receiver distance) at 2 positions over the occipital cortex (t-test: t(8) = -2.672, p = 0.028 < 0.05 for position 1, t(8) = -2.874, p = 0.021 < 0.05 for position 2). In contrast, no statistically significant change is seen when a short-distance probe (16mm source-receiver distance) is used (t-test: t(8) = -2.043, p = 0.075 > 0.05 for position 1, t(8) = -2.146, p = 0.064 > 0.05 for position 2). The enhanced dynamics observed with DWS is positively correlated with the functional increase of blood volume in the visual cortex, while the heartbeat rate is not affected by stimulation. Our results indicate that the DWS signal from the visual cortex is governed by the regional cerebral blood flow velocity.

© 2007 Optical Society of America

OCIS Codes
(030.6140) Coherence and statistical optics : Speckle
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.5270) Medical optics and biotechnology : Photon density waves
(170.5280) Medical optics and biotechnology : Photon migration
(290.1350) Scattering : Backscattering
(290.1990) Scattering : Diffusion

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: March 22, 2007
Revised Manuscript: May 5, 2007
Manuscript Accepted: May 9, 2007
Published: May 15, 2007

Virtual Issues
Vol. 2, Iss. 6 Virtual Journal for Biomedical Optics

Citation
Franck Jaillon, Jun Li, Gregor Dietsche, Thomas Elbert, and Thomas Gisler, "Activity of the human visual cortex measured non-invasively by diffusing-wave spectroscopy," Opt. Express 15, 6643-6650 (2007)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-15-11-6643


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