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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 15, Iss. 12 — Jun. 11, 2007
  • pp: 7335–7350

Feasibility of near-infrared diffuse optical spectroscopy on patients undergoing image-guided core-needle biopsy

Bing Yu, Elizabeth S. Burnside, Gale A. Sisney, Josephine M. Harter, Changfang Zhu, Al-Hafeez Dhalla, and Nirmala Ramanujam  »View Author Affiliations

Optics Express, Vol. 15, Issue 12, pp. 7335-7350 (2007)

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We describe a side-firing fiber optic sensor based on near-infrared spectroscopy for guiding core needle biopsy diagnosis of breast cancer. The sensor is composed of three side firing optical fibers (two source fibers and one detection fiber), providing two source-detector separations. The entire assembly is inserted into a core biopsy needle, allowing for sampling to occur at the biopsy site. A multi-wavelength frequency-domain near-infrared instrument is used to collect diffuse reflectance in the breast tissue through an aperture on the biopsy needle before the tissue is removed for histology. Preliminary in vivo measurements performed on 10 normal or benign breast tissues from 5 women undergoing stereo- or ultrasound-guided core needle biopsy show the ability of the system to determine tissue optical properties and constituent concentrations, which are correlated with breast tissue composition derived from histopathology.

© 2007 Optical Society of America

OCIS Codes
(170.1610) Medical optics and biotechnology : Clinical applications
(170.4730) Medical optics and biotechnology : Optical pathology
(170.5270) Medical optics and biotechnology : Photon density waves
(170.5280) Medical optics and biotechnology : Photon migration
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: March 30, 2007
Revised Manuscript: May 24, 2007
Manuscript Accepted: May 30, 2007
Published: May 31, 2007

Virtual Issues
Vol. 2, Iss. 7 Virtual Journal for Biomedical Optics

Bing Yu, Elizabeth S. Burnside, Gale A. Sisney, Josephine M. Harter, Changfang Zhu, Al-Hafeez Dhalla, and Nirmala Ramanujam, "Feasibility of near-infrared diffuse optical spectroscopy on patients undergoing imageguided core-needle biopsy," Opt. Express 15, 7335-7350 (2007)

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