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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 15, Iss. 12 — Jun. 11, 2007
  • pp: 7610–7615

Silicon-on-Insulator microring resonator for sensitive and label-free biosensing

Katrien De Vos, Irene Bartolozzi, Etienne Schacht, Peter Bienstman, and Roel Baets  »View Author Affiliations

Optics Express, Vol. 15, Issue 12, pp. 7610-7615 (2007)

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Label-free biosensors attempt to overcome the stability and reliability problems of biosensors relying on the detection of labeled molecules. We propose a label-free biosensor based on microring cavities in Silicon-on-Insulator (SOI) that fits in an area below 10x10μm2. The resonance wavelength shift that occurs when the surroundings of a cavity is changed, is used for sensing. While theoretically the performance for bulk refractive index changes is moderate (10-5), this device performs outstanding in terms of absolute molecular mass sensing (theoretical sensitivity of 1fg molecular mass) thanks to its extremely small dimensions. We use the avidin/biotin high affinity couple to demonstrate good repeatability and detection of protein concentrations down to 10ng/ml. Fabrication with Deep UV lithography allows for cheap mass production and integration with electronic functions for complete lab-on-chip devices.

© 2007 Optical Society of America

OCIS Codes
(130.3120) Integrated optics : Integrated optics devices
(130.6010) Integrated optics : Sensors
(230.5750) Optical devices : Resonators

ToC Category:
Integrated Optics

Original Manuscript: March 27, 2007
Revised Manuscript: May 30, 2007
Manuscript Accepted: May 30, 2007
Published: June 6, 2007

Virtual Issues
Vol. 2, Iss. 7 Virtual Journal for Biomedical Optics

Katrien De Vos, Irene Bartolozzi, Etienne Schacht, Peter Bienstman, and Roel Baets, "Silicon-on-Insulator microring resonator for sensitive and label-free biosensing," Opt. Express 15, 7610-7615 (2007)

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