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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 15, Iss. 15 — Jul. 23, 2007
  • pp: 9139–9146

Analysis of biomolecule detection with optofluidic ring resonator sensors

Hongying Zhu, Ian M. White, Jonathan D. Suter, Paul S. Dale, and Xudong Fan  »View Author Affiliations


Optics Express, Vol. 15, Issue 15, pp. 9139-9146 (2007)
http://dx.doi.org/10.1364/OE.15.009139


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Abstract

We theoretically and experimentally analyze the biomolecule detection capability of the liquid core optical ring resonator (LCORR) as a label-free bio/chemical sensor. We first establish a simple and general linear relationship between the LCORR’s bulk refractive index sensitivity (BRIS) and its response to molecule deposition onto the surface, which enables us to easily characterize the LCORR sensing performance. Then, biosensing experiments are performed with bovine serum albumin (BSA) and LCORRs of various BRISs. The experimental results are in good agreement with the theoretical prediction. Further analysis shows that the LCORR is capable of detecting BSA below 10 pM with sub-picogram/mm2 mass detection limit.

© 2007 Optical Society of America

OCIS Codes
(120.1880) Instrumentation, measurement, and metrology : Detection
(170.4520) Medical optics and biotechnology : Optical confinement and manipulation
(230.5750) Optical devices : Resonators
(300.6490) Spectroscopy : Spectroscopy, surface

ToC Category:
Instrumentation, Measurement, and Metrology

History
Original Manuscript: May 7, 2007
Revised Manuscript: June 6, 2007
Manuscript Accepted: July 9, 2007
Published: July 11, 2007

Virtual Issues
Vol. 2, Iss. 8 Virtual Journal for Biomedical Optics

Citation
Hongying Zhu, Ian M. White, Jonathan D. Suter, Paul S. Dale, and Xudong Fan, "Analysis of biomolecule detection with optofluidic ring resonator sensors," Opt. Express 15, 9139-9146 (2007)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-15-15-9139


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