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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 15, Iss. 15 — Jul. 23, 2007
  • pp: 9722–9730

Adaptive-mesh-based algorithm for fluorescence molecular tomography using an analytical solution

Daifa Wang, Xiaolei Song, and Jing Bai  »View Author Affiliations


Optics Express, Vol. 15, Issue 15, pp. 9722-9730 (2007)
http://dx.doi.org/10.1364/OE.15.009722


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Abstract

Fluorescence molecular tomography (FMT) has become an important method for in-vivo imaging of small animals. It has been widely used for tumor genesis, cancer detection, metastasis, drug discovery, and gene therapy. In this study, an algorithm for FMT is proposed to obtain accurate and fast reconstruction by combining an adaptive mesh refinement technique and an analytical solution of diffusion equation. Numerical studies have been performed on a parallel plate FMT system with matching fluid. The reconstructions obtained show that the algorithm is efficient in computation time, and they also maintain image quality.

© 2007 Optical Society of America

OCIS Codes
(110.6960) Imaging systems : Tomography
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.6280) Medical optics and biotechnology : Spectroscopy, fluorescence and luminescence

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: March 20, 2007
Revised Manuscript: May 30, 2007
Manuscript Accepted: May 30, 2007
Published: July 19, 2007

Virtual Issues
Vol. 2, Iss. 8 Virtual Journal for Biomedical Optics

Citation
Daifa Wang, Xiaolei Song, and Jing Bai, "Adaptive-mesh-based algorithm for fluorescence molecular tomography using an analytical solution," Opt. Express 15, 9722-9730 (2007)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-15-15-9722


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